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Effects of antidepressant drugs and GR 205171, an neurokinin-1 (NK1) receptor antagonist, on the response in the forced swim test and on monoamine extracellular levels in the frontal cortex of the
TLDR
Results suggest that FST response may not be related to levels of monoamines in the mouse frontal cortex, and fluoxetine augmented all monoamines, bupropion enhanced catecholamines, and GR 205171 was totally ineffective. Expand
Zacopride: anxiolytic profile in rodent and primate models of anxiety
TLDR
It is concluded that the 5‐HT3 receptor antagonist, zacopride, alters rodent and primate behaviour in a manner consistent with that of an anxiolytic agent. Expand
Evaluation of the effects of lamotrigine, valproate and carbamazepine in a rodent model of mania
TLDR
It is proposed that hyperactivity induced by D-amphetamine/chlordiazepoxide may arise through dopaminergic drive coupled with disinhibition caused by low doses of the benzodiazepine, and the efficacy of lamotrigine may then arise through a reduction in neuronal excitability or increased glutamate transmission, these latter a consequence of the disinhibited. Expand
The effects of ondansetron, a 5-HT3 receptor antagonist, on cognition in rodents and primates
TLDR
It is concluded that ondansetron potently improves basal performance in rodent and primate tests of cognition and inhibits the impairments in performance caused by cholinergic deficits. Expand
Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders.
TLDR
A novel, drug-like bis-amido piperidine derivative was identified as potent dual OX(1) and OX (2) receptor antagonists, highly effective in a pre-clinical model of sleep. Expand
Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist
TLDR
In rodents, ropinirole, like apomorphine, caused biphasic spontaneous locomotor activity and contralateral circling in 6-OHDA-lesioned mice with no tolerance to the latter after 14 days treatment, and these results support the continued clinical assessment of ro pinirole for the treatment of Parkinson's disease. Expand
Effects of captopril and SQ29,852 on anxiety-related behaviours in rodent and marmoset
TLDR
It is concluded that captopril and SQ29,852 have an anxiolytic profile of action in 3 species, that cessation of treatment is not associated with a withdrawal syndrome, that the ACE inhibitors cross tolerate with diazepam and can antagonise the behavioural consequences of withdrawal from treatment with drugs of abuse. Expand
The effect of ondansetron on cognitive performance in the marmoset
TLDR
It is shown that ondansetron at low doses is able to improve the performance of marmosets in a cognitive task, which would support the concept that a 5-HT3 receptor antagonist can act as a cognitive enhancer. Expand
Ondansetron and arecoline prevent scopolamine-induced cognitive deficits in the marmoset
TLDR
Ondansetron prevents impairment in the cognitive performance of marmosets induced by administration of scopolamine, a model of cognitive impairment induced by the muscarinic receptor antagonist, scopolamines. Expand
Anxiolytic profile of ropinirole in the rat, mouse and common marmoset
TLDR
Ropinirole did not compromise the effect of amitriptyline in the Porsolt test of depression and in itself produced antidepressant-like effects and may predict an action of ropinirole in man that would provide a superior profile of action over other presently available anti-parkinsonian agents. Expand
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