Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Regulation of Expression of the Multidrug Resistance-Associated Protein 2 (MRP2) and Its Role in Drug Disposition
The multidrug resistance protein 2 (MRP2; ABCC2) is an ATP-binding cassette transporter accepting a diverse range of substrates, including glutathione, glucuronide, and sulfate conjugates of many… Expand
Active Transport of Nitrofurantoin into Human Milk
- P. Gerk, R. Kuhn, N. Desai, P. McNamara
- Medicine
- Pharmacotherapy
- 1 June 2001
Study Objective. To determine the extent to which nitrofurantoin is transferred into human milk.
Therapeutic promises of 2-methoxyestradiol and its drug disposition challenges.
- S. Verenich, P. Gerk
- Chemistry, Medicine
- Molecular pharmaceutics
- 6 December 2010
2-Methoxyestradiol (2MeO-E2) is an endogenous metabolite of estrogen which was initially considered to be inactive. During the last few decades it has been shown that 2MeO-E2 is a promising… Expand
Interactions between cimetidine, nitrofurantoin, and probenecid active transport into rat milk.
- P. Gerk, C. Y. Oo, E. Paxton, J. Moscow, P. McNamara
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 2001
The purpose of these studies was to further elucidate the active mammary epithelial transport processes for the organic cation cimetidine and the organic anion nitrofurantoin and to determine which… Expand
ESTRADIOL 3-GLUCURONIDE IS TRANSPORTED BY THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2 BUT DOES NOT ACTIVATE THE ALLOSTERIC SITE BOUND BY ESTRADIOL 17-GLUCURONIDE
β-Estradiol 17-(β-d-glucuronide) (E217G) is a well known cholestatic agent and substrate of multidrug resistance-associated protein 2 (Mrp2), whereas β-estradiol 3-(β-d-glucuronide) (E23G) is a… Expand
The Role of Protein Synthesis and Degradation in the Post-Transcriptional Regulation of Rat Multidrug Resistance-Associated Protein 2 (Mrp2, Abcc2)
- B. R. Jones, W. Li, J. Cao, T. Hoffman, P. Gerk, M. Vore
- Biology, Medicine
- Molecular Pharmacology
- 1 September 2005
Multidrug resistance-associated protein 2 (Mrp2, Abcc2), an organic anion transporter present in the apical membrane of hepatocytes, renal epithelial cells, and enterocytes, is postulated to undergo… Expand
"Clicked" bivalent ligands containing curcumin and cholesterol as multifunctional abeta oligomerization inhibitors: design, synthesis, and biological characterization.
- J. A. Lenhart, Xiao Ling, +4 authors Shijun Zhang
- Chemistry, Medicine
- Journal of medicinal chemistry
- 28 July 2010
In our effort to develop multifunctional compounds that cotarget beta-amyloid oligomers (AbetaOs), cell membrane/lipid rafts (CM/LR), and oxidative stress, a series of bivalent multifunctional Abeta… Expand
Basolateral active uptake of nitrofurantoin in the CIT3 cell culture model of lactation.
- P. Gerk, J. Moscow, P. McNamara
- Biology, Medicine
- Drug metabolism and disposition: the biological…
- 1 June 2003
Nitrofurantoin and other agents are actively transported into human and rodent milk. The purpose of this study was to determine whether nitrofurantoin active transport across mammary epithelia occurs… Expand
Formation and efflux of ATP-binding cassette transporter substrate 2,4-dinitrophenyl-S-glutathione from cultured human term placental villous tissue fragments.
- Soniya S Vaidya, S. Walsh, P. Gerk
- Chemistry, Medicine
- Molecular pharmaceutics
- 1 November 2009
Upon exposure to 1-chloro-2,4-dinitrobenzene (CDNB), the human placental tissue forms its glutathione conjugate 2,4-dinitrophenyl-S-glutathione (DNP-SG). The purpose of this study was to investigate… Expand
Role of placental ATP-binding cassette (ABC) transporters in antiretroviral therapy during pregnancy.
Highly active anti-retroviral therapy (HAART) is used to treat HIV-infected patients and involves administration of multiple antiretroviral drugs acting at different steps of the HIV life cycle. In… Expand