Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air.
Fluoranthene is an important volatile PAH because it occurs at high concentrations in ambient air and because it is an experimental carcinogen in certain test systems, and a tentative guideline value of 2 ng/m(3) is suggested for fluoranthene.
The rapid alveolar absorption of diesel soot-adsorbed benzo[a]pyrene: bioavailability, metabolism and dosimetry of an inhaled particle-borne carcinogen.
The results indicate that absorption through the alveolar epithelium is an important route of entry to the circulation of unmetabolized PAHS in a model polycyclic aromatic hydrocarbon and a typical carrier particle.
Solution-engineered palladium nanoparticles: model for health effect studies of automotive particulate pollution.
The studies demonstrate cellular uptake of Pd nanoparticles only in PBEC, as determined by TEM, with pronounced and dose-dependent effects on cellular secretion of soluble biomarkers in both cell types and a decreased responsiveness of human epithelial cells to the pro-inflammatory cytokine TNF-α.
Challenges in inhaled product development and opportunities for open innovation.
In vivo deposition of ultrafine aerosols in the nasal airway of the rat.
Toxicity of lunar dust
DissolvIt: An In Vitro Method for Simulating the Dissolution and Absorption of Inhaled Dry Powder Drugs in the Lungs.
This study indicates that DissolvIt simulates dissolution and absorption of drugs in the lung, and that dissolving particles diffused through the barrier and was absorbed into the perfusate.
Disposition of polycyclic aromatic hydrocarbons in the respiratory tract of the beagle dog. I. The alveolar region.
- P. Gerde, B. Muggenburg, Mark D. Hoover, R. Henderson
- Medicine, BiologyToxicology and Applied Pharmacology
- 1 August 1993
The results indicate that inhaled PAHs of sufficient lipophilicity to limit diffusion through cells have a greater potential for toxicity to the lung than less lipophilicPAHs.
Local metabolism in lung airways increases the uncertainty of pyrene as a biomarker of polycyclic aromatic hydrocarbon exposure.
Results support the inference that lipophilic protoxicants, because of slow, diffusion-limited absorption, are more likely than water-soluble protoxicant to be bioactivated in the lining epithelium and, in turn, induce first-pass toxicity at the site of entry.
Dry powder inhalation exposures of the endotracheally intubated rat lung, ex vivo and in vivo: the pulmonary pharmacokinetics of fluticasone furoate.
- E. Selg, P. Ewing, F. Acevedo, Carl-Olof Sjöberg, A. Ryrfeldt, P. Gerde
- Medicine, BiologyJournal of Aerosol Medicine
- 26 July 2013
The results indicate that the IPL and the EIR, when used jointly in PK studies, can provide a detailed characterization of inhaled drugs or toxicants.