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- Publications
- Influence
Subunit‐dependent oxidative stress sensitivity of LRRC8 volume‐regulated anion channels
- A. Gradogna, P. Gavazzo, A. Boccaccio, M. Pusch
- Medicine, Chemistry
- The Journal of physiology
- 1 November 2017
Swelling‐activated anion currents are modulated by oxidative conditions, but it is unknown if oxidation acts directly on the LRRC8 channel‐forming proteins or on regulatory factors. We found that… Expand
Electro-magnetic field promotes osteogenic differentiation of BM-hMSCs through a selective action on Ca2+-related mechanisms
- L. Petecchia, F. Sbrana, +5 authors P. Gavazzo
- Chemistry, Medicine
- Scientific reports
- 14 September 2015
Exposure to Pulsed Electromagnetic Field (PEMF) has been shown to affect proliferation and differentiation of human mesenchymal stem cells derived from bone marrow stroma (BM-hMSC). These cells offer… Expand
NMDA receptors as targets of heavy metal interaction and toxicity
- C. Marchetti, P. Gavazzo
- Chemistry, Medicine
- Neurotoxicity Research
- 1 September 2005
TheN-methyl-D-aspartate (NMDA) receptor (NR) is a ligand-gated channel that carries the slow component of the glutamate-activated postsynaptic current. Divalent metal ions can affect the NR channel… Expand
Molecular determinants of Pb2+ interaction with NMDA receptor channels
- P. Gavazzo, I. Zanardi, I. Baranowska-Bosiacka, C. Marchetti
- Medicine, Chemistry
- Neurochemistry International
- 31 January 2008
Lead (Pb2+) is a potent neurotoxin that acts as a non-competitive, voltage-independent antagonist of the NMDA receptor (NR) channel. Pb2+ action partially overlaps with that of zinc (Zn2+), but… Expand
Subunit-dependent effects of nickel on NMDA receptor channels.
- C. Marchetti, P. Gavazzo
- Biology, Medicine
- Brain research. Molecular brain research
- 7 October 2003
Nickel (Ni2+) is a transition metal that affects different neuronal ionic channels. We investigated its effects on glutamate channels of the NMDA-type in the presence of saturating concentration of… Expand
Susceptibility of insulinoma cells to cadmium and modulation by L-type calcium channels
- P. Gavazzo, E. Morelli, C. Marchetti
- Medicine, Chemistry
- Biometals
- 1 April 2005
Cadmium (Cd), a toxic metal that induces apoptosis and necrosis in a variety of cells, accumulates in pancreas and may be a cause of diabetes in humans. In the insulinoma cells line HIT-T15 (HIT), we… Expand
Molecular Determinants of Multiple Effects of Nickel on NMDA Receptor Channels
- P. Gavazzo, P. Guida, I. Zanardi, C. Marchetti
- Medicine, Chemistry
- Neurotoxicity Research
- 5 February 2009
Nickel (Ni2+) is a toxic metal that affects the function of several neuronal ionic channels. Ni2+ inhibits N-methyl-d-aspartate receptor (NR) channel in a voltage-dependent manner, but also causes… Expand
Nickel modulates the electrical activity of cultured cortical neurons through a specific effect on N-methyl-d-aspartate receptor channels
- P. Gavazzo, M. Tedesco, M. Chiappalone, I. Zanardi, C. Marchetti
- Biology, Medicine
- Neuroscience
- 17 March 2011
Nickel (Ni(2+)) is a toxic metal that affects the function of several ionic channels. In the N-methyl-d-aspartate (NMDA) subtype of glutamate receptor (NR), it causes activity enhancement of the… Expand
Ethidium bromide intercalation and chromatin structure: a spectropolarimetric analysis.
- L. Vergani, P. Gavazzo, G. Mascetti, C. Nicolini
- Chemistry, Medicine
- Biochemistry
- 31 May 1994
Native chromatin has been characterized at different ionic strengths, according to different methods of preparation, by means of circular dichroism and ethidium bromide intercalation. For a more… Expand
The P2X7 receptor as a route for non‐exocytotic glutamate release: dependence on the carboxyl tail
- C. Cervetto, S. Alloisio, +7 authors M. Marcoli
- Biology, Medicine
- Journal of neurochemistry
- 1 March 2013
P2X7 receptors trigger Ca2+‐dependent exocytotic glutamate release, but also function as a route for non‐exocytotic glutamate release from neurons or astrocytes. To gain an insight into the… Expand