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Subunit‐dependent oxidative stress sensitivity of LRRC8 volume‐regulated anion channels
Swelling‐activated anion currents are modulated by oxidative conditions, but it is unknown if oxidation acts directly on the LRRC8 channel‐forming proteins or on regulatory factors. We found thatExpand
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Electro-magnetic field promotes osteogenic differentiation of BM-hMSCs through a selective action on Ca2+-related mechanisms
Exposure to Pulsed Electromagnetic Field (PEMF) has been shown to affect proliferation and differentiation of human mesenchymal stem cells derived from bone marrow stroma (BM-hMSC). These cells offerExpand
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NMDA receptors as targets of heavy metal interaction and toxicity
TheN-methyl-D-aspartate (NMDA) receptor (NR) is a ligand-gated channel that carries the slow component of the glutamate-activated postsynaptic current. Divalent metal ions can affect the NR channelExpand
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Molecular determinants of Pb2+ interaction with NMDA receptor channels
Lead (Pb2+) is a potent neurotoxin that acts as a non-competitive, voltage-independent antagonist of the NMDA receptor (NR) channel. Pb2+ action partially overlaps with that of zinc (Zn2+), butExpand
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Subunit-dependent effects of nickel on NMDA receptor channels.
Nickel (Ni2+) is a transition metal that affects different neuronal ionic channels. We investigated its effects on glutamate channels of the NMDA-type in the presence of saturating concentration ofExpand
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Susceptibility of insulinoma cells to cadmium and modulation by L-type calcium channels
Cadmium (Cd), a toxic metal that induces apoptosis and necrosis in a variety of cells, accumulates in pancreas and may be a cause of diabetes in humans. In the insulinoma cells line HIT-T15 (HIT), weExpand
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Molecular Determinants of Multiple Effects of Nickel on NMDA Receptor Channels
Nickel (Ni2+) is a toxic metal that affects the function of several neuronal ionic channels. Ni2+ inhibits N-methyl-d-aspartate receptor (NR) channel in a voltage-dependent manner, but also causesExpand
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Nickel modulates the electrical activity of cultured cortical neurons through a specific effect on N-methyl-d-aspartate receptor channels
Nickel (Ni(2+)) is a toxic metal that affects the function of several ionic channels. In the N-methyl-d-aspartate (NMDA) subtype of glutamate receptor (NR), it causes activity enhancement of theExpand
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Ethidium bromide intercalation and chromatin structure: a spectropolarimetric analysis.
Native chromatin has been characterized at different ionic strengths, according to different methods of preparation, by means of circular dichroism and ethidium bromide intercalation. For a moreExpand
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The P2X7 receptor as a route for non‐exocytotic glutamate release: dependence on the carboxyl tail
P2X7 receptors trigger Ca2+‐dependent exocytotic glutamate release, but also function as a route for non‐exocytotic glutamate release from neurons or astrocytes. To gain an insight into theExpand
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