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Control of neuronal differentiation by sumoylation of BRAF35, a subunit of the LSD1-CoREST histone demethylase complex
The LSD1–CoREST histone demethylase complex is required to repress neuronal genes in nonneuronal tissues. Here we show that sumoylation of Braf35, one of the subunits of the complex, is required toExpand
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Association of bromodomain BET proteins with chromatin requires dimerization through the conserved motif B
Summary BET (bromodomain and extra terminal domain) family proteins are unique among bromodomain-containing proteins in that they not only associate with acetylated chromatin in interphase, but alsoExpand
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Pleiotrophin antagonizes Brd2 during neuronal differentiation
ABSTRACT Bromodomain-containing protein 2 (Brd2) is a BET family chromatin adaptor required for expression of cell-cycle-associated genes and therefore involved in cell cycle progression. Brd2 isExpand
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The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators
Covalent attachment of small ubiquitin‐like modifier (SUMO) to proteins regulates many processes in the eukaryotic cell. This reaction is similar to ubiquitination and usually requires an E3 ligaseExpand
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Novel inhibitors to Taenia solium Cu/Zn superoxide dismutase identified by virtual screening
We describe in this work a successful virtual screening and experimental testing aimed to the identification of novel inhibitors of superoxide dismutase of the worm Taenia solium (TsCu/Zn–SOD), a human parasite. Expand
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The Cornelia de Lange Syndrome-associated factor NIPBL interacts with BRD4 ET domain for transcription control of a common set of genes
Mutations in NIPBL are the major cause of Cornelia de Lange Syndrome (CdLS). NIPBL is the cohesin-loading factor and has recently been associated with the BET (bromodomains and extra-terminal (ET)Expand
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Función de Brd2 en la coordinación entre proliferación y diferenciación en el sistema nervioso central de vertebrados
Trabajo realizado en el Departamento de Celulas Troncales, Reprogramacion y Diferenciacion Celular, CABIMER, para optar al grado de Doctor en Biologia por el Licenciado Pablo Garcia Gutierrez,Expand
Dimerization through the conserved motif B is involved in chromatin association and function of bromodomain BET proteins
Poster presentado al 22nd IUBMB & 37th FEBS Congress: From Single Molecules to Systems Biology, celebrado en Sevilla (Espana) del 4 al 9 de septiembre de 2012
Pleiotrophin fights Brd2 for neuronal differentiation
Work in M G-D lab is supported by Ministry of Economy and Competitiveness, Spain (MINECO), grant number BFU2012-37304, and by Junta de Andalucia, Spain, grant number P12-CTS-2064.