Role of Endothelial Dysfunction in Atherosclerosis
- J. Davignon, P. Ganz
- Biology, MedicineCirculation
- 15 June 2004
Clinical trials have shown that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) improve endothelial dysfunction in patients with coronary risk factors beyond what could be attributed to their impact on plasma lipids.
Close relation of endothelial function in the human coronary and peripheral circulations.
- T. Anderson, A. Uehata, A. Yeung
- Medicine, BiologyJournal of the American College of Cardiology
- 1 November 1995
Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial.
- S. Nissen, E. Tuzcu, A. DeMaria
- MedicineJAMA
- 3 March 2004
For patients with coronary heart disease, intensive lipid-lowering treatment with atorvastatin reduced progression of coronary atherosclerosis compared with pravastatin.
Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries.
The preliminary findings suggest that the abnormal vascular response to acetylcholine may represent a defect in endothelial vasodilator function, and may be important in the pathogenesis of coronary vasospasm.
Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial.
- G. Schwartz, A. Olsson, T. Stern
- MedicineJAMA
- 1 September 2001
The Assessment of Endothelial Function: From Research Into Clinical Practice
- A. Flammer, T. Anderson, A. Lerman
- Biology, MedicineCirculation
- 7 August 2012
The assessment of its vasodilator properties resulting from NO and other molecules may provide information on the integrity and function of the endothelium, and most, if not all, cardiovascular risk factors are associated with endothelial dysfunction, and risk factor modification leads to improvement in vascular function.
Is there a menopausal syndrome? Menopausal status and symptoms across racial/ethnic groups.
- N. Avis, R. Stellato, M. Kagawa-Singer
- Psychology, MedicineSocial Science & Medicine ()
- 1 February 2001
Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.
- H. Ting, F. Timimi, K. Boles, S. Creager, P. Ganz, M. Creager
- Medicine, BiologyJournal of Clinical Investigation
- 1996
It is concluded that endothelial dysfunction in forearm resistance vessels of patients with non-insulin-dependent diabetes mellitus can be improved by administration of the antioxidant, vitamin C, and support the hypothesis that nitric oxide inactivation by oxygen-derived free radicals contributes to abnormal vascular reactivity in diabetes.
The effect of atherosclerosis on the vasomotor response of coronary arteries to mental stress.
- A. Yeung, V. Vekshtein, A. Selwyn
- Medicine, BiologyNew England Journal of Medicine
- 28 November 1991
Atherosclerosis disturbs the normal vasomotor response (no change or dilation) of large coronary arteries to mental stress; in patients with atherosclerosis paradoxical constriction occurs during mental stress, particularly at points of stenosis.
Effects of the Direct Lipoprotein-Associated Phospholipase A2 Inhibitor Darapladib on Human Coronary Atherosclerotic Plaque
- P. Serruys, H. Garcia-Garcia, A. Zalewski
- MedicineCirculation
- 9 September 2008
Comparing the effects of 12 months of treatment with darapladib or placebo on coronary atheroma deformability and plasma high-sensitivity C-reactive protein in 330 patients with angiographically documented coronary disease suggests that Lp-PLA2 inhibition may represent a novel therapeutic approach.
...
...