• Publications
  • Influence
Great ape genetic diversity and population history
Most great ape genetic variation remains uncharacterized; however, its study is critical for understanding population history, recombination, selection and susceptibility to disease. Here we sequenceExpand
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Microsatellite scoring errors associated with noninvasive genotyping based on nuclear DNA amplified from shed hair
In the context of a study of wild chimpanzees, Pan troglodytes verus, we found that genotypes based on single PCR amplifications of microsatellite loci from single shed hair have a high error rate.Expand
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Mitochondrial sequences show diverse evolutionary histories of African hominoids.
Phylogenetic trees for the four extant species of African hominoids are presented, based on mtDNA control region-1 sequences from 1,158 unique haplotypes. We include 83 new haplotypes of westernExpand
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Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid
Humans are genetically unable to produce the sialic acid N-glycolylneuraminic acid (Neu5Gc), because of a mutation that occurred after our last common ancestor with great apes. Although Neu5Gc isExpand
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Evolutionary considerations in relating oligosaccharide diversity to biological function.
The oligosaccharide chains (glycans) attached to cell surface and extracellular proteins and lipids are known to mediate many important biological roles. However, for many glycans, there are still noExpand
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Multifarious roles of sialic acids in immunity
  • A. Varki, P. Gagneux
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • 1 April 2012
Sialic acids are a diverse family of monosaccharides widely expressed on all cell surfaces of vertebrates and so‐called “higher” invertebrates, and on certain bacteria that interact with vertebrates.Expand
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Innovations in host and microbial sialic acid biosynthesis revealed by phylogenomic prediction of nonulosonic acid structure
Sialic acids (Sias) are nonulosonic acid (NulO) sugars prominently displayed on vertebrate cells and occasionally mimicked by bacterial pathogens using homologous biosynthetic pathways. It has beenExpand
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Evolution of human-chimpanzee differences in malaria susceptibility: relationship to human genetic loss of N-glycolylneuraminic acid.
Chimpanzees are the closest evolutionary cousins of humans, sharing >99% identity in most protein sequences. Plasmodium falciparum is the major worldwide cause of malaria mortality. PlasmodiumExpand
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Alu-mediated inactivation of the human CMP- N-acetylneuraminic acid hydroxylase gene
Inactivation of the CMP-N-acetylneuraminic acid hydroxylase gene has provided an example of human-specific genomic mutation that results in a widespread biochemical difference between human andExpand
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Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase
BackgroundInfluenza A virus (IAV) neuraminidase (NA) cleaves sialic acids (Sias) from glycans. Inhibiting NA with oseltamivir suppresses both viral infection, and viral release from cultured humanExpand
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