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Novel MRI Contrast Agent for Molecular Imaging of Fibrin: Implications for Detecting Vulnerable Plaques
Fibrin clots targeted in vitro with paramagnetic nanoparticles presented a highly detectable, homogeneous T1-weighted contrast enhancement that improved with increasing gadolinium level, suggesting that molecular imaging of fibrin-targeted param magnetic nanoparticles can provide sensitive detection and localization offibrin.
Quantitative “magnetic resonance immunohistochemistry” with ligand‐targeted 19F nanoparticles
The extension of 19F imaging and spectroscopy techniques to a clinically relevant application, the evaluation of the fibrin burden within an ex vivo human carotid endarterectomy sample, demonstrates the potential use of these particles for uniquely identifying unstable atherosclerotic lesions in vivo.
Textilinins from Pseudonaja textilis textilis. Characterization of two plasmin inhibitors that reduce bleeding in an animal model
- P. Masci, A. Whitaker, P. Gaffney
- Biology, ChemistryBlood coagulation & fibrinolysis : an…
- 1 June 2000
It is proposed that the kinetic profiles of Txln 1 and 2 for plasmin allow the arrest of haemorrhage without the possible threat of thrombosis.
A novel site-targeted ultrasonic contrast agent with broad biomedical application.
These data provide the first in vivo demonstration of a site-specific ultrasonic contrast agent and have potential for improved sensitivity and specificity for noninvasive diagnosis of thrombi and other pathological diseases.
High‐resolution MRI characterization of human thrombus using a novel fibrin‐targeted paramagnetic nanoparticle contrast agent
The results suggest the potential for sensitive and specific detection of microthrombi that form on the intimal surfaces of unstable atherosclerotic plaque and targeted contrast agent dramatically improved the detectability of all clots.
In Vitro Demonstration Using 19F Magnetic Resonance to Augment Molecular Imaging With Paramagnetic Perfluorocarbon Nanoparticles at 1.5 Tesla
19F MRI/S molecular imaging of perfluorocarbon nanoparticles in vitro suggests that noninvasive phenotypic characterization of pathologic biosignatures is feasible at clinical field strengths.
Ligand-directed nanobialys as theranostic agent for drug delivery and manganese-based magnetic resonance imaging of vascular targets.
- D. Pan, S. Caruthers, G. Lanza
- Biology, ChemistryJournal of the American Chemical Society
- 24 June 2008
A complementary ability of nanobialys to incorporate chemotherapeutic compounds with greater than 98% efficiency and to retain more than 80% of these drugs after infinite sink dissolution, point to the theranostic potential of this platform technology.
A performance evaluation of commercial fibrinogen reference preparations and assays for Clauss and PT-derived fibrinogen.
Clauss Assays are generally reproducible between centres, analysers and reagents, but PT-Fg assays are not reliable in clinical settings, and ELISA and immunonephelometric assays correlated well, but with a high degree of scatter.
Gadolinium‐modulated 19F signals from perfluorocarbon nanoparticles as a new strategy for molecular imaging
By directly incorporating a relaxation agent, gadolinium (Gd), into the lipid monolayer that surrounds the perfluorocarbon (PFC), a marked augmentation of the 19F signal from 200‐nm nanoparticles was achieved and forms the basis for designing contrast agents capable of sensing their surface chemistry.
A collaborative study to establish the 2nd International Standard for Fibrinogen, Plasma.
The ampouled and freeze-dried residue of solvent/detergent treated plasma was the candidate replacement standard and was calibrated as coded duplicates versus the 1st IS Fibrinogen, Plasma by automated Clauss assay and by a recommended clot collection (gravimetric) assay.