P. G. Czyryca

Publications8
h-index6
Citations186
Highly Influential Citations1
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Synthesis and Combinational Antibacterial Study of 5″-Modified Neomycin
A library of 5″-modified neomycin derivatives were synthesized for an antibacterial structure–activity optimization strategy. Two leads exhibited prominent activity against both methicillin-resistant… Expand
  • 32
  • 1
Surprising alteration of antibacterial activity of 5"-modified neomycin against resistant bacteria.
A facile synthetic protocol for the production of neomycin B derivatives with various modifications at the 5'' position has been developed. The structural activity relationship (SAR) against… Expand
  • 64
Glycodiversification for the optimization of the kanamycin class aminoglycosides.
  • J. Wang, J. Li, +5 authors C. Chang
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2 September 2005
In an effort to optimize the antibacterial activity of kanamycin class aminoglycoside antibiotics, we have accomplished the synthesis and antibacterial assay of new kanamycin B analogues. A… Expand
  • 27
Application of glycodiversification: expedient synthesis and antibacterial evaluation of a library of kanamycin B analogues.
[reaction: see text] The expedient synthesis of a library of kanamycin B analogues is reported. The revealed SAR will guide future designs in developing kanamycin-type aminoglycoside antibiotics… Expand
  • 35
Synthesis of an unusual branched-chain sugar, 5-C-methyl-L-idopyranose for SAR studies of pyranmycins: implication for the future design of aminoglycoside antibiotics.
The syntheses of a challenging branched-chain sugar and several L-sugars have been accomplished. Their application in studies of the antibacterial activity of pyranmycins is reported, which could… Expand
  • 15
Design and synthesis of pyrankacin: a pyranmycin class of broad-spectrum aminoglycoside antibiotic.
A novel broad-spectrum aminoglycoside antibiotic, pyrankacin, has been prepared. In addition to the synthetic innovation in dideoxygenation and regioselective Staudinger reduction, we have obtained… Expand
  • 13
Application of Glycodiversification: Expedient Synthesis and Antibacterial Evaluation of a Library of Kanamycin B Analogues.
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