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In vitro antiviral activity of Melaleuca alternifolia essential oil
Aims:  To investigate the in vitro antiviral activity of Melaleuca alternifolia essential oil (TTO) and its main components, terpinen‐4‐ol, α‐terpinene, γ‐terpinene, p‐cymene, terpinolene andExpand
Combining molecular modeling with experimental methodologies: mechanism of membrane permeation and accumulation of ofloxacin.
In vitro experiments show that a suitable balance of hydrophilic and hydrophobic fluoroquinolone properties needs to occur for there to be increased drug permeation, and demonstrate that a pH gradient through model membranes may be responsible for a poorly homogeneous distribution of ofloxacin. Expand
Ofloxacin-Loaded Liposomes: In Vitro Activity and Drug Accumulation in Bacteria
The liposome formulation produced higher intracellular fluoroquinolone concentrations than those achieved simultaneously with the free drug in both E. coli and P. aeruginosa, and provided the best improvement in antimicrobial activity against the various bacterial strains investigated. Expand
Formulation parameters of fluoroquinolone-loaded liposomes and in vitro antimicrobial activity☆
Abstract To load pefloxacin and ofloxacin in liposomes, two preparation procedures were carried out, leading to the formation of multilamellar vesicles (MLVs) or reverse-phase evaporation vesiclesExpand
In vitro antimycoplasmal activity of Citrus bergamia essential oil and its major components.
The results indicated that C. bergamia essential oil and its major components had shown an interesting in vitro antimycoplasmal activity. Expand
Topical Kanamycin: an Effective Therapeutic Option in Aerobic Vaginitis
The data suggest that the topical use of kanamycin could be considered a specific antibiotic for the therapy of this new pathology of aerobic vaginitis. Expand
Intracellular accumulation of ofloxacin-loaded liposomes in human synovial fibroblasts
The reverse-phase evaporation technique was carried out and the liposome formulation was able to deliver ofloxacin into McCoy cells in a greater amount than the free drug, improving antibiotic accumulation. Expand
Antibiotic Susceptibility of Respiratory Pathogens Recently Isolated in Italy: Focus on Cefditoren
Cefditoren's wide spectrum and high intrinsic activity, as well as its capacity to overcome most of the resistance that has become consolidated in some classes of antibiotics widely used as empiric therapy for CARTI, allows it to be suggested that cefditore might be included in the european guidelines as one of the first-choice antibiotics in the treatment of C ARTI. Expand
Antimicrobial and Anti-Proliferative Effects of Skin Mucus Derived from Dasyatis pastinaca (Linnaeus, 1758)
Assessment of the antimicrobial and anti-proliferative effects of skin mucus derived from Dasyatis pastinaca showed that fish mucus exhibited a significant and specific antibacterial activity against Gram-negative bacteria but not against gram-positive bacteria. Expand
Synergism and postantibiotic effect of tobramycin and Melaleuca alternifolia (tea tree) oil against Staphylococcus aureus and Escherichia coli.
In vitro interactions can improve the antimicrobial effectiveness of the antibiotic and may contribute for the development of novel topical agents for the treatment of skin lesions including conjunctiva and respiratory infections by inhalation. Expand