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Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
TLDR
Mendelian randomisation analyses challenge the concept that raising of plasma HDL cholesterol will uniformly translate into reductions in risk of myocardial infarction. Expand
A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease
TLDR
A GWAS meta-analysis of CAD cases and controls provides a comprehensive survey of the fine genetic architecture of CAD, showing that genetic susceptibility to this common disease is largely determined by common SNPs of small effect size. Expand
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
TLDR
A genome-wide association study of type-2 diabetes in individuals of South Asian ancestry provides additional insight into mechanisms underlying T2D and shows the potential for new discovery from genetic association studies in South Asians. Expand
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
TLDR
A significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association is observed, and considerable improvements in the fine-mapping resolution of common variant association signals at several T1D susceptibility loci are observed. Expand
Factors Associated with Adherence to Anti-Hypertensive Treatment in Pakistan
TLDR
In contrast, monotherapy reduced adherence, whereas psychosocial factors such as depression showed no association, which may be used to identify the subset of population at risk of low adherence who should be targeted for interventions to achieve better blood pressure control and hence prevent complications. Expand
ANGPTL3 Deficiency and Protection Against Coronary Artery Disease.
TLDR
ANGPTL3 deficiency is associated with protection from CAD, and individuals in the lowest tertile of circulating ANGPTL 3 concentrations, compared with the highest, had reduced odds of MI. Expand
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
TLDR
A meta-analysis of four large genome-wide association studies of CAD found a CAD-associated SNP in the PDGFD locus showed tissue-specific cis expression quantitative trait locus effects, implicate new pathways for CAD susceptibility. Expand
Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms
TLDR
25 new SNP–CAD associations are identified from 15 genomic regions, including SNPs in or near genes involved in cellular adhesion, leukocyte migration and atherosclerosis, coagulation and inflammation and vascular smooth muscle cell differentiation, which sheds light on potential disease mechanisms. Expand
Congenital insensitivity to pain with anhidrosis: novel mutations in the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor.
TLDR
11 novel mutations are reported, distributed in an extracellular domain, involved in NGF binding, as well as the intracellular signal-transduction domain, that suggest that TRKA defects cause CIPA in various ethnic groups. Expand
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