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Memory Reconsolidation and Extinction Have Distinct Temporal and Biochemical Signatures
Memory retrieval is not a passive phenomenon. Instead, it triggers a number of processes that either reinforce or alter stored information. Retrieval is thought to activate a second memoryExpand
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The organization of recent and remote memories
A fundamental question in memory research is how our brains can form enduring memories. In humans, memories of everyday life depend initially on the medial temporal lobe system, including theExpand
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Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus
Throughout adulthood, new neurons are continuously added to the dentate gyrus, a hippocampal subregion that is important in spatial learning. Whether these adult-generated granule cells becomeExpand
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The Involvement of the Anterior Cingulate Cortex in Remote Contextual Fear Memory
Although the molecular, cellular, and systems mechanisms required for initial memory processing have been intensively investigated, those underlying permanent memory storage remain elusive. WeExpand
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CREB and memory.
The cAMP responsive element binding protein (CREB) is a nuclear protein that modulates the transcription of genes with cAMP responsive elements in their promoters. Increases in the concentration ofExpand
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Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy
Forget It! When examining the relationship between the production of new neurons in the hippocampus and memory, studies have generally first manipulated hippocampal neurogenesis and afterwardExpand
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Optical controlling reveals time-dependent roles for adult-born dentate granule cells
Accumulating evidence suggests that global depletion of adult hippocampal neurogenesis influences its function and that the timing of the depletion affects the deficits. However, the behavioral rolesExpand
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The dorsal hippocampus is essential for context discrimination but not for contextual conditioning.
The authors describe how (a) the timing of hippocampal lesions and (b) the behavioral-representational demands of the task affect the requirement for the hippocampus in contextual fear conditioning.Expand
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Sensorimotor gating abnormalities in young males with fragile X syndrome and Fmr1-knockout mice
Fragile X syndrome (FXS) is the most common single gene (FMR1) disorder affecting cognitive and behavioral function in humans. This syndrome is characterized by a cluster of abnormalities includingExpand
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Involvement of the Anterior Cingulate Cortex in the Expression of Remote Spatial Memory
Although the hippocampus plays a crucial role in the formation of spatial memories, as these memories mature they may become additionally (or even exclusively) dependent on extrahippocampalExpand
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