P. Frankland

Publications204
h-index66
Citations20,269
Highly Influential Citations1,113
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Memory Reconsolidation and Extinction Have Distinct Temporal and Biochemical Signatures
TLDR
The temporal dynamics of memory reconsolidation are dependent on the strength and age of the memory, such that younger and weaker memories are more easily reconsolidated than older and stronger memories.
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The organization of recent and remote memories
TLDR
Recent studies have begun to shed light on how remote memories are organized in the cortex, and the molecular and cellular events that underlie their consolidation.
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Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus
TLDR
It is shown that as new granule cells mature, they are increasingly likely to be incorporated into circuits supporting spatial memory, which supports the idea that new neurons make a unique contribution to memory processing in the dentate gyrus.
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The Involvement of the Anterior Cingulate Cortex in Remote Contextual Fear Memory
Although the molecular, cellular, and systems mechanisms required for initial memory processing have been intensively investigated, those underlying permanent memory storage remain elusive. We…
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CREB and memory.
TLDR
Evidence from Aplysia, Drosophila, mice, and rats shows that CREB-dependent transcription is required for the cellular events underlying long-term but not short-term memory, indicating thatCREB may be a universal modulator of processes required for memory formation.
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Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy
TLDR
Throughout life, new neurons are continuously added to the dentate gyrus, and as this continuous addition remodels hippocampal circuits, computational models predict that neurogenesis leads to degradation or forgetting of established memories.
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The dorsal hippocampus is essential for context discrimination but not for contextual conditioning.
TLDR
Together, these data dissociate hippocampal and nonhippocampal contributions to contextual conditioning, and they provide direct evidence that the hippocampus plays an essential role in the processing of contextual stimuli.
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Optical controlling reveals time-dependent roles for adult-born dentate granule cells
TLDR
Reversibly silencing this cohort of ∼4-week-old cells after training, but not cells of other ages, substantially disrupted retrieval of hippocampal memory, identifying a restricted time window for adult-born neurons essential in hippocampusal memory retrieval.
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Involvement of the Anterior Cingulate Cortex in the Expression of Remote Spatial Memory
TLDR
Evidence is provided that circuits supporting spatial memory are reorganized in a time-dependent manner, and that activity in neurons intrinsic to the ACC is critical for processing remote spatial memories.
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Sensorimotor gating abnormalities in young males with fragile X syndrome and Fmr1-knockout mice
TLDR
It is shown that young males with FXS have profound deficits in prepulse inhibition (PPI), a basic marker of sensorimotor gating that has been extensively studied in rodents, and this suggests that murine compensatory mechanisms following loss of FMR1 function differ from those in humans.
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