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Sleep deprivation in rats: effects on EEG power spectra, vigilance states, and cortical temperature.
Vigilance states, electroencephalogram (EEG) power spectra (0.25-25.0 Hz), and cortical temperature (TCRT) of 10 rats were obtained during a baseline day, a 24-h sleep deprivation (SD) period, and 2Expand
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The Homeostatic Regulation of Sleep Need Is under Genetic Control
Delta power, a measure of EEG activity in the 1–4 Hz range, in slow-wave sleep (SWS) is in a quantitative and predictive relationship with prior wakefulness. Thus, sleep loss evokes a proportionalExpand
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Homer1a is a core brain molecular correlate of sleep loss
Sleep is regulated by a homeostatic process that determines its need and by a circadian process that determines its timing. By using sleep deprivation and transcriptome profiling in inbred mouseExpand
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Role of Melanopsin in Circadian Responses to Light
Melanopsin has been proposed as an important photoreceptive molecule for the mammalian circadian system. Its importance in this role was tested in melanopsin knockout mice. These mice entrained to aExpand
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Altered Patterns of Sleep and Behavioral Adaptability in NPAS2-Deficient Mice
Animal behavior is synchronized to the 24-hour light:dark (LD) cycle by regulatory programs that produce circadian fluctuations in gene expression throughout the body. In mammals, the transcriptionExpand
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Genetic determinants of sleep regulation in inbred mice.
Genetic variation in the expression and regulation of sleep was assessed in six inbred mice strains (AK, C, B6, BR, D2, 129). The amount, distribution, and fragmentation of the behavioral statesExpand
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The CaV3.3 calcium channel is the major sleep spindle pacemaker in thalamus
Low-threshold (T-type) Ca2+ channels encoded by the CaV3 genes endow neurons with oscillatory properties that underlie slow waves characteristic of the non-rapid eye movement (NREM) sleep EEG. ThreeExpand
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Separating the contribution of glucocorticoids and wakefulness to the molecular and electrophysiological correlates of sleep homeostasis.
STUDY OBJECTIVES The sleep-deprivation-induced changes in delta power, an electroencephalographical correlate of sleep need, and brain transcriptome profiles have importantly contributed to currentExpand
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Melanopsin as a Sleep Modulator: Circadian Gating of the Direct Effects of Light on Sleep and Altered Sleep Homeostasis in Opn4−/− Mice
Analyses in mice deficient for the blue-light-sensitive photopigment melanopsin show that direct effects of light on behavior and EEG depend on the time of day. The data further suggest an unexpectedExpand
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Genetic variation in EEG activity during sleep in inbred mice.
The genetic variation in spontaneous rhythmic electroencephalographic (EEG) activity was assessed by the quantitative analysis of the EEG in six inbred mice strains. Mean spectral EEG profiles (0-25Expand
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