• Publications
  • Influence
Genetic and Physical Interactions Involving the Yeast Nuclear Cap-Binding Complex
ABSTRACT Yeast strains lacking the yeast nuclear cap-binding complex (yCBC) are viable, although impaired in growth. We have taken advantage of this observation to carry out a genetic screen forExpand
  • 87
  • 17
  • PDF
Epigenetic silencing of the tumor suppressor microRNA Hsa-miR-124a regulates CDK6 expression and confers a poor prognosis in acute lymphoblastic leukemia.
Whereas transcriptional silencing of genes due to epigenetic mechanisms is one of the most important alterations in acute lymphoblastic leukemia (ALL), some recent studies indicate that DNAExpand
  • 274
  • 15
  • PDF
A Human Sequence Homologue of Staufen Is an RNA-Binding Protein That Is Associated with Polysomes and Localizes to the Rough Endoplasmic Reticulum
ABSTRACT In the course of a two-hybrid screen with the NS1 protein of influenza virus, a human clone capable of coding for a protein with high homology to the Staufen protein from DrosophilaExpand
  • 178
  • 15
The Mammalian Staufen Protein Localizes to the Somatodendritic Domain of Cultured Hippocampal Neurons: Implications for Its Involvement in mRNA Transport
In hippocampal neurons, certain mRNAs have been found in dendrites (Steward, 1997), and their localization and translation have been implicated in synaptic plasticity (Martin et al., 1997). OneExpand
  • 275
  • 14
  • PDF
Adenovirus Virus-Associated RNA Is Processed to Functional Interfering RNAs Involved in Virus Production
ABSTRACT Posttranscriptional gene silencing allows sequence-specific control of gene expression. Specificity is guaranteed by small antisense RNAs such as microRNAs (miRNAs) or small interfering RNAsExpand
  • 161
  • 13
  • PDF
Negative regulation of the interferon response by an interferon-induced long non-coding RNA
Long non-coding RNAs (lncRNAs) play critical roles in diverse cellular processes; however, their involvement in many critical aspects of the immune response including the interferon (IFN) responseExpand
  • 120
  • 10
  • PDF
microRNA-451 Regulates Macrophage Migration Inhibitory Factor Production and Proliferation of Gastrointestinal Cancer Cells
Purpose: microRNAs (miRNA) are small RNAs that function as post-transcriptional regulators of gene expression. Recent evidence has shown that some miRNAs can act as oncogenes or tumor suppressors.Expand
  • 342
  • 9
  • PDF
Participation of the nuclear cap binding complex in pre-mRNA 3' processing.
Communication between the 5' and 3' ends is a common feature of several aspects of eukaryotic mRNA metabolism. In the nucleus, the pre-mRNA 5' end is bound by the nuclear cap binding complex (CBC).Expand
  • 203
  • 9
Luc7p, a novel yeast U1 snRNP protein with a role in 5' splice site recognition.
The characterization of a novel yeast-splicing factor, Luc7p, is presented. The LUC7 gene was identified by a mutation that causes lethality in a yeast strain lacking the nuclear cap-binding complexExpand
  • 102
  • 8
The yeast nuclear cap binding complex can interact with translation factor eIF4G and mediate translation initiation.
The mRNA cap structure is bound by either the nuclear (CBC) or the cytoplasmic (eIF4F) cap binding complex. Following mRNA export, CBC must be exchanged for eIF4F in the cytoplasm. It is not knownExpand
  • 90
  • 8