Glucagon-like peptide 1 (GLP-1)
Dipeptidyl peptidase IV (DPP IV) inhibitors: a newly emerging drug class for the treatment of type 2 diabetes
In clinical trials DPP IV inhibitors (or ‘gliptins’) have shown efficacy and tolerability in the management of hyperglycaemia in type 2 diabetes, without causing weight gain or hypoglycaemia.
Inhibition of dipeptidyl peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1.
The effects of traditional antidiabetic plants on in vitro glucose diffusion
Insulin-releasing and insulin-like activity of the traditional anti-diabetic plant Coriandrum sativum (coriander)
The presence of antihyperglycaemic, insulin-releasing and insulin-like activity in Coriandrum sativum is demonstrated and sequential extraction with solvents revealed insulin- releasing activity in hexane and water fractions indicating a possible cumulative effect of more than one extract constituent.
Inhibition of dipeptidyl peptidase IV activity by oral metformin in Type 2 diabetes
This work investigated the acute effects of metformin on DPP IV activity in Type 2 diabetes to elucidate inhibition of DPPIV as a possible mechanism of action.
Characterization of a Novel Glucose-Responsive Insulin-Secreting Cell Line, BRIN-BD11, Produced by Electrofusion
High-performance liquid chromatography analysis demonstrated that insulin was the major product secreted under stimulatory conditions, and western blotting confirmed that BRIN-BD11 cells expressed the GLUT2 glucose transporter, confirming an intact glucose sensing mechanism.
GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet.
- P. McClean, N. Irwin, R. Cassidy, J. Holst, V. Gault, P. Flatt
- Biology, MedicineAmerican Journal of Physiology. Endocrinology and…
- 1 December 2007
Data indicate that GIP receptor antagonism using (Pro(3))GIP provides an effective means of countering obesity and related diabetes induced by consumption of a high-fat, energy-rich diet.
Soluble dietary fibre fraction of Trigonella foenum-graecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and…
The present findings indicate that the SDF fraction of T. foenum-graecum seeds exerts antidiabetic effects mediated through inhibition of carbohydrate digestion and absorption, and enhancement of peripheral insulin action.