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Altered striatal activation predicting real-world positive affect in adolescent major depressive disorder.
OBJECTIVE Alterations in reward-related brain function and phenomenological aspects of positive affect are increasingly examined in the development of major depressive disorder. The authors testedExpand
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Acute 5-HT Reuptake Blockade Potentiates Human Amygdala Reactivity
Variability in serotonin (5-HT) function is associated with individual differences in normal mood and temperament, as well as psychiatric illnesses, all of which are influenced by amygdala function.Expand
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Effects of HTR1A C(-1019)G on amygdala reactivity and trait anxiety.
CONTEXT Serotonin 1A (5-hydroxytryptamine 1A [5-HT(1A)]) autoreceptors mediate negative feedback inhibition of serotonergic neurons and play a critical role in regulating serotonin signaling involvedExpand
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Cortical surface-based analysis reduces bias and variance in kinetic modeling of brain PET data
TLDR
This work explores how preprocessing choices affect the bias and variability of voxelwise kinetic modeling analysis of brain positron emission tomography (PET) data. Expand
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FKBP5 and emotional neglect interact to predict individual differences in amygdala reactivity.
Individual variation in physiological responsiveness to stress mediates risk for mental illness and is influenced by both experiential and genetic factors. Common polymorphisms in the human gene forExpand
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Functional connectivity of the dorsal and median raphe nuclei at rest
TLDR
A novel multimodal neuroimaging approach for investigating resting-state functional connectivity (FC) between DR and MR and cortical, subcortical and cerebellar target areas. Expand
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A high-resolution in vivo atlas of the human brain's serotonin system.
The serotonin (5-HT) system modulates many important brain functions and is critically involved in many neuropsychiatric disorders. We here present a high-resolution multi-dimensional in vivo atlasExpand
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Interaction between trait anxiety and trait anger predict amygdala reactivity to angry facial expressions in men but not women.
The amygdala is critically involved in mediating physiological and behavioral responses to threat. In particular, neuroimaging research indicates that the amygdala is highly responsive to facialExpand
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Capacity for 5-HT1A–mediated autoregulation predicts amygdala reactivity
We examined the contribution of 5-HT1A autoreceptors (with [11C]WAY100635 positron emission tomography) to amygdala reactivity (with blood oxygenation level–dependent functional magnetic resonanceExpand
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