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Poly(amido‐amine)s: Biomedical Applications
Poly(amido-amine)s (PAAs) are synthetic tert-amino polymers obtained by stepwise polyaddition of primary or secondary aliphatic amines to bis(acrylamide)s. Linear polymers are produced during theExpand
A Biodegradable Polymeric Carrier Based on PEG for Drug Delivery
A biodegradable copolymer (PEG-fum), based on poly(ethylene glycol) (PEG) and fumarate (fum) units, was synthesized and studied as a drug carrier. PEG and fum were linked together by ester bonds toExpand
New synthetic amphiphilic polymers for steric protection of liposomes in vivo.
At low polymer concentration, amphiphilic branched poly(ethylene glycol) seems to be the most effective liposomes protector, most probably, because at the same molar content of anchoring groups, each attachment point carries two polymeric chains and doubles the quantity of liposome-grafted polymer comparing to linear poly( methylene gly col). Expand
Poly(amidoamine)s as potential endosomolytic polymers: evaluation in vitro and body distribution in normal and tumour-bearing animals.
PAAs have potential as endosomolytic agents and quantitation of the endosome to cytoplasm transfer is warranted after i.v. administration, and biodistribution studies in mice bearing subcutaneous B16F10 melanoma showed that 125I-labelled ISA 22 was still accumulating in tumour tissue after 5 h (2.5% dose/g). Expand
New poly(amidoamine)s containing disulfide linkages in their main chain
Novel poly(amidoamine)s (PAAs) containing disulfide linkages regularly arranged along their backbones were synthesized by the stepwise polyaddition of 2-methylpiperazine to N,N-bis(acryloyl)cystamineExpand
Poly(amidoamine)s as potential nonviral vectors: ability to form interpolyelectrolyte complexes and to mediate transfection in vitro.
PAAs demonstrated the ability to mediate pSV beta-galactosidase transfections of HepG2 cells and showed equivalent transfection ability compared with polyethylenimine and LipofectIN and was more effective than LipofECTACE, suggesting that PAAs warrant further development as endosomolytic vectors. Expand
Poly(amidoamine)s: Past, present, and perspectives
Poly(amidoamine)s (PAAs) are a family of synthetic polymers obtained by stepwise polyaddition of prim- or sec-amines to bisacrylamides. Nearly all conceivable bisacrylamides and prim- or sec-aminesExpand
Effects of branched or linear architecture of bioreducible poly(amido amine)s on their in vitro gene delivery properties.
The results show the large possibilities for this class of polymers to provide polymeric vectors with controllable properties for gene therapy applications and the ease of synthetic modification of both linear and hyperbranched poly(amido amide)s and the versatility of hyperbrANChed PAAs in regulating DNA transfection and cytotoxicity. Expand
Poly(amidoamine) conjugates containing doxorubicin bound via an acid-sensitive linker.
The results suggest that ISA23Dox is able to release biologically active Dox in vitro and that this conjugate might be suitable for further development. Expand
A luminescent poly(amidoamine)-iridium complex as a new singlet-oxygen sensitizer for photodynamic therapy.
Results indicate that cell damage induced by 1M was avoided by binding the iridium sensitizers to the poly(amidoamine), and both 1M and 1P are efficient cell staining agents endowed with two-photon excitation (TPE) imaging capability. Expand