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FK506 can activate transforming growth factor-beta signalling in vascular smooth muscle cells and promote proliferation.
AIMS FK506-binding protein (FKBP) 12 is an inhibitor of transforming growth factor (TGF)-beta type I receptors. Several lines of evidence support the view that TGF-beta stimulates vascular smoothExpand
Hemodynamic effects of magnesium sulfate on the normal human heart.
Abstract Because of its antiarrhythmic properties,1 parenteral magnesium sulfate has been widely used in the last decades in treating several supraventricular or ventricular arrhythmias2,3 even inExpand
Tirofiban induces VEGF production and stimulates migration and proliferation of endothelial cells.
Tirofiban is a fibrinogen receptor antagonist, generated using the tripeptide Arg-Gly-Asp (RGD) as a template. RGD activates integrin receptors and integrin-mediated signals are necessary for normalExpand
Comparative one-month safety and effectiveness of five leading new-generation devices for transcatheter aortic valve implantation
Transcatheter aortic valve implantation (TAVI) for aortic stenosis is becoming an appealing alternative to surgical aortic valve replacement in high-risk patients and to medical therapy forExpand
[A case of percutaneous coronary intervention after transfemoral implantation of a medtronic CoreValve System].
The association between aortic valve disease and coronary atherosclerosis is common. In the recent era of transcatheter aortic valve implantation there is little experience with coronary arteryExpand
History of Paroxysmal, Persistent, Long-Standing or Permanent Atrial Fibrillation in Patients Undergoing Transcatheter Mitral Valve Repair with Mitraclip: Does it Matter?
Background: Atrial Fibrillation (AF) may impact adversely on mitral valve function. Transcatheter Mitral Valve Repair (TMVR) with MitraClip is considered an acceptable alternative to surgical repairExpand
Rapamycin antagonizes NF-κB nuclear translocation activated by TNF-α in primary vascular smooth muscle cells and enhances apoptosis
Several lines of evidence support the view that rapamycin inhibits NF-κB. TNF-α, a potent inducer of NF-κB, is released after artery injury (e.g., balloon angioplasty) and plays an important role i...
Outcome of Patients Undergoing Transcatheter Aortic Valve Implantation After Prior Balloon Aortic Valvuloplasty.
OBJECTIVES Transcatheter aortic valve implantation (TAVI) is an effective treatment for severe aortic stenosis. Yet, balloon aortic valvuloplasty (BAV) is still occasionally offered to apparentlyExpand
TCT-319 Comparative effectiveness and safety of five leading new-generation TAVI devices: early results from the RISPEVA Study
Transcatheter aortic valve implantation (TAVI) for aortic stenosis is becoming an appealing alternative to surgical aortic valve replacement in high-risk patients and to medical therapy forExpand
Reduced left ventricular mechanical efficiency in elderly patients with coronary artery disease
We evaluated left ventricular (LV) mechanical efficiency in 23 elderly patients (mean age 67± 2) with coronary artery disease (CAD) and in 22 patients younger than 65 years (mean age 49± 8) withExpand
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