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A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention.
TLDR
Oral nicotinamide was safe and effective in reducing the rates of new nonmelanoma skin cancers and actinic keratoses in high-risk patients and there was no evidence of benefit after nicotinamide was discontinued.
Cutaneous manifestations of dabrafenib (GSK2118436): a selective inhibitor of mutant BRAF in patients with metastatic melanoma
TLDR
A systematic prospective dermatological review of all patients enrolled at a single institution in the phase I/II clinical trial of the mutant BRAF inhibitor dabrafenib (GSK2118436) found that cutaneous reactions are frequent and significant.
Cutaneous Toxic Effects of BRAF Inhibitors Alone and in Combination With MEK Inhibitors for Metastatic Melanoma.
TLDR
Although CombiDT therapy has an improved profile of cutaneous toxic effects, continuous dermatologic assessments should be provided for all patients when receiving these treatments.
Consensus recommendations on the use of daylight photodynamic therapy with methyl aminolevulinate cream for actinic keratoses in Australia
TLDR
Daylight PDT with methyl aminolevulinate (MAL) cream is a simple treatment for AK, almost painless, well tolerated and convenient, requiring minimal time in the clinic, and can be included as an effective and well tolerated new treatment option for the treatment of AK in Australia.
Panniculitis in Patients Treated With BRAF Inhibitors: A Case Series
TLDR
Panniculitis seems to be a rare class effect of BRAF inhibitors that is predominantly lobular and neutrophilic, although other patterns can be seen.
Mutational analysis of cutaneous squamous cell carcinomas and verrucal keratosis in patients taking BRAF inhibitors
TLDR
It is suggested that verrucal keratosis is an early clinical presentation of cuSCC in patients on BRAFi, and upstream mutations in RAS as well as PIK3CA are found in both verruca‐like and cutaneous squamous cell carcinomas.
Behaviour, attitudes and awareness concerning sun exposure in adolescents on the Costa del sol
TLDR
Adolescents comprise a special risk group with a positive attitude towards tanning, and further studies are required to assess educational stategies in order to reduce the desire to have a suntan, and improve sun protection practices and habits targeted at this age group.
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