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Substrate turnover during prolonged exercise in man. Splanchnic and leg metabolism of glucose, free fatty acids, and amino acids.
Blood glucose levels fall because hepatic glucose output fails to keep up with augmented glucose utilization by the exercising legs, and augmented secretion of glucagon may play an important role in the metabolic adaptation to prolonged exercise by its stimulatory influence on hepatic glycogenolysis and gluconeogenesis. Expand
Amino acid metabolism in man.
  • P. Felig
  • Biology, Medicine
  • Annual review of biochemistry
  • 1975
This review will focus on recent studies in which amino acid exchange between various organs has been examined in a variety of physiologic and pathologic conditions in intact humans, with particular emphasis on the relationship of amino acid metabolism to gluconeogenesis, its interaction with glucoregulatory hormones, and its role in nitrogen exchange. Expand
Glucose metabolism during leg exercise in man.
It is concluded that blood glucose becomes an increasingly important substrate for muscle oxidation during prolonged exercise of this type and peripheral glucose utilization increases in exercise despite a reduction in circulating insulin levels. Expand
Amino acid metabolism in exercising man.
  • P. Felig, J. Wahren
  • Chemistry, Medicine
  • The Journal of clinical investigation
  • 1 December 1971
The data suggest that synthesis of alanine in muscle, presumably by transamination of glucose-derived pyruvate, is increased in exercise probably as a consequence of increased availability of pyruVate and amino groups; circulating alanines serves an important carrier function in the transport of amino groups from peripheral muscle to the liver, particularly during exercise. Expand
Lactate and glucose exchange across the forearm, legs, and splanchnic bed during and after prolonged leg exercise.
It is concluded that during prolonged leg exercise at 58% maximum O(2) uptake an imbalance between splanchnic glucose production and leg glucose utilization results in a fall in blood glucose that may reach hypoglycemic levels in healthy subjects. Expand
Plasma amino acid levels and insulin secretion in obesity.
Hyperaminoacidemia appears to be a manifestation of the insulin ineffectiveness characteristic of obesity, and may provide the feedback signal to the beta cell through which insulin resistance is accompanied by an appropriately augmented secretory rate of insulin. Expand
Endocrinology and Metabolism
General Endocrinology Introduction to the Endocrine Neuroendocrinology and the Pituitary Thyroid Disease Adrenal Disease Gonadal Disease Fuel Metabolism Calcium and Bone Metabolism MiscellaneousExpand
Effect of protein ingestion on splanchnic and leg metabolism in normal man and in patients with diabetes mellitus.
The inter-organ flux of substrates after a protein-rich meal was studied in seven healthy subjects and in eight patients, with diabetes mellitus, and there was a large amino acid release from the splanchnic bed predominantly involving the branched chain amino acids. Expand
Synergistic interaction between exercise and insulin on peripheral glucose uptake.
The results demonstrate that (a) insulin and exercise act synergistically to enhance glucose disposal in man, and (b) muscle is the primary tissue responsible for the increase in glucose metabolism following hyperinsulinemia and exercise. Expand
Fuel homeostasis in exercise.
The purpose of this communication is to review the patterns of fuel utilization and production during exercise and emphasis will be placed on glucose homeostasis and the hormonal factors that contribute to its regulation. Expand