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Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics
Background The first line treatment for Chagas disease, a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi, involves administration of benznidazole (Bzn). Bzn is aExpand
Extracellular vesicles carrying lactate dehydrogenase induce suicide in increased population density of Plasmodium falciparum in vitro
Evidence is presented of the EV-associated PfLDH regulation of parasite population by inducing apoptosis in highly parasitized cultures by inducing programmed cell death processes in the population. Expand
Trypanosoma cruzi chemical proteomics using immobilized benznidazole.
The untargeted search for Bzn binding partners allowed for proteins that could be related to drug reductive activation and/or resistance mechanisms to be encountered, including the aldo-ketoreductase family member TcAKR. Expand
Imidazolium compounds are active against all stages of Trypanosoma cruzi.
Results demonstrate that the test agents with the best profile are those bearing symmetrical bulky substituents at N(1) and N(3), displaying promising activity against all forms of T. cruzi, interesting selectivity indexes and exceptional activity at low doses, represent promising candidates for the treatment of Chagas disease. Expand
A Nature-Inspired Design Yields a New Class of Steroids Against Trypanosomatids
The best compound, a steroidal thiosemicarbazone compound 8 (ID_1260) was active in vitro (IC50 200 nM) and in vivo (60% infection reduction at 50 mg/kg) in Leishmania and T. cruzi, being a promising compound for anti-trypanosomatid drug development. Expand
Redox metabolism in Trypanosoma cruzi. Biochemical characterization of dithiol glutaredoxin dependent cellular pathways.
The influence of TcrGrx in several parasite physiological processes suggests novel insights about the protein involvement in redox signaling, and a dithiolic glutaredoxin with deglutathionylating activity is characterized, having potential functionality to control intracellular homeostasis of protein and non-protein thiols. Expand
Autochthonous Outbreak and Expansion of Canine Visceral Leishmaniasis, Uruguay
The findings document an expansion of visceral leishmaniasis to southern South America and risk for vectorborne transmission to humans. Expand
Selenosemicarbazones as potent cruzipain inhibitors and their antiparasitic properties against Trypanosoma cruzi
The cysteine protease cruzipain is an essential T. cruzienzyme and one of the few validated drug targets for Chagas disease. Thiosemicarbazones have been described as cruzipain inhibitors. WhileExpand
Cytotoxic, Virucidal, and Antiviral Activity of South American Plant and Algae Extracts
Most interesting antiviral activity values obtained are those of Limonium brasiliense, Psidium guajava, and Phyllanthus niruri, which inhibit HSV-1 replication in vitro with 50% effective concentration (EC50) values of 185, 118, and 60 μg/mL, respectively. Expand
Early Trypanosoma cruzi Infection Triggers mTORC1-Mediated Respiration Increase and Mitochondrial Biogenesis in Human Primary Cardiomyocytes
Early during infection, the activation of mTORC1, mitochondrial biogenesis and improvement in oxidative phosphorylation are key biochemical changes that provide new insights into the host response to parasite infection and the pathogenesis of chronic chagasic cardiomyopathy. Expand