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Effect of lung volume reduction surgery on neuromechanical coupling of the diaphragm.
The mechanisms for symptomatic improvement following lung volume reduction surgery for emphysema are poorly understood. We hypothesized that enhanced neuromechanical coupling of the diaphragm is anExpand
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Reconciling in vitro and in vivo measurements of aerosol delivery from a metered-dose inhaler during mechanical ventilation and defining efficiency-enhancing factors.
We attempted to resolve the discrepancies in reported data on aerosol deposition from a chlorofluorocarbon (CFC)-propelled metered-dose inhaler (MDI) during mechanical ventilation, obtained by inExpand
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Dose-response to bronchodilator delivered by metered-dose inhaler in ventilator-supported patients.
In nonintubated patients, metered-dose inhalers (MDIs) are accepted as the most convenient, efficient, and cost effective method of administering inhaled bronchodilators. Recent studies haveExpand
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Effect of the rebreathing pattern on pulmonary tissue volume and capillary blood flow.
Noninvasive rebreathing measurements of pulmonary tissue volume (Vt) and pulmonary capillary blood flow (Qc) theoretically and experimentally vary with the rebreathing maneuver. To determine theExpand
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Structural change of the thorax in chronic obstructive pulmonary disease.
This study examines structural changes of the thorax in hyperinflated subjects with chronic obstructive pulmonary disease (COPD). Age-matched normal subjects were used for comparison. ThoracicExpand
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Clinical experience with continuous monitoring of mixed venous oxygen saturation in respiratory failure.
The amount of oxygen in mixed venous blood (SvO2) is a reliable indicator of the status of oxygenation of tissue in most clinical settings. Monitoring levels of SvO2 might, therefore, aid in managingExpand
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Preferential pulmonary retention of (S)-albuterol after inhalation of racemic albuterol.
The (R)-enantiomer of racemic albuterol produces bronchodilation, whereas the (S)-enantiomer may increase airway reactivity. After oral or intravenous administration of racemic albuterol, the (R)-Expand
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Serum albuterol levels in mechanically ventilated patients and healthy subjects after metered-dose inhaler administration.
In mechanically ventilated patients, systemic blood levels of inhaled drugs reflect absorption from the lower respiratory tract alone since, unlike nonintubated patients, oropharyngeal andExpand
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Effect of lung volume reduction surgery on diaphragmatic neuromechanical coupling at 2 years.
STUDY OBJECTIVES We previously reported that patients with emphysema show an increase in diaphragmatic neuromechanical coupling at 3 months after lung volume reduction surgery. DiaphragmaticExpand
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Hypoxemic respiratory failure complicating nosocomial measles in a healthy host.
Since 1983 there has been a steady increase in the number of cases of measles reported to the Centers for Disease Control (CDC), and recent large-scale outbreaks have heightened public awareness.Expand
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