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Attenuation of p53 Expression Protects against Focal Ischemic Damage in Transgenic Mice
- R. Crumrine, Amy L. Thomas, P. F. Morgan
- BiologyJournal of cerebral blood flow and metabolism…
- 1 November 1994
The data suggest that attenuated p53 expression may be protective after an ischemic event, and that grater protection was afforded by reduced expression of p53.
The nature and timing of excitotoxic neuronal necrosis in the cerebral cortex, hippocampus and thalamus due to flurothyl-induced status epilepticus
The results showed that acidophilic neurons appeared simultaneously in neurons of the neocortex, hippocampus and thalamus, and that this occurred within 1 h following the end of the epilepsy, which supports an excitotoxic mechanism in epilepsy-induced selective neuronal necrosis also in brain regions outside the hippocampus.
Adenosinergic modulation of caffeine-induced c-fos mRNA expression in mouse brain
Mapping rat brain structures activated during ethanol withdrawal: role of glutamate and NMDA receptors.
Adenosine uptake site heterogeneity in the mammalian CNS? Uptake inhibitors as probes and potential neuropharmaceuticals.
Interactions between calcium channel compounds and adenosine systems in brain of rat
Ontogenetic Profile of the Adenosine Uptake Sites in Rat Forebrain
- P. F. Morgan, P. Montgomery, P. Marangos
- Biology, ChemistryJournal of neurochemistry
- 1 September 1987
The ontogenetic profile of [3H]CHA appears to coincide with synaptogenesis whereas that of [2H]NBI does not, and the binding of [ 3H?]NBI in 6‐day‐old tissue to be indistinguishable from such binding in 30‐day-old tissue.
The novel anticonvulsant lamotrigine prevents dopamine depletion in C57 black mice in the MPTP animal model of Parkinson's disease.
Broad spectrum anticonvulsant activity of BW534U87: possible role of an adenosine-dependent mechanism
Caffeine-induced seizures: apparent proconvulsant action of N-ethyl carboxamidoadenosine (NECA).