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BAR Domains as Sensors of Membrane Curvature: The Amphiphysin BAR Structure
TLDR
The structure of the Drosophila amphiphysin BAR domain is solved and it is predicted that BAR domains are in many protein families, including sorting nexins, centaurins, and oligophrenins.
Curvature of clathrin-coated pits driven by epsin
TLDR
It is shown here that epsin 1 directly modifies membrane curvature on binding to PtdIns(4,5)P2 in conjunction with clathrin polymerization, and it is proposed that this helix is inserted into one leaflet of the lipid bilayer, inducing curvature.
Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes.
TLDR
The structure of the NH2-terminal domain of CALM bound to phosphatidylinositol-4,5- bisphosphate [PtdIns( 4,5)P2] via a lysine-rich motif is presented, and it is shown that AP180 may serve to tether clathrin to the membrane simultaneously, and was shown by using purified components and a budding assay on preformed lipid monolayers.
Crystal structure at 1.92 Å resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin
TLDR
The crystal structure of the RNA-binding domain of the small nuclear ribonucleoprotein U1A bound to a 21-nucleotide RNA hairpin has been determined and reveals the stereochemical basis for sequence-specific RNA recognition by the RNP domain.
Mechanism of endophilin N‐BAR domain‐mediated membrane curvature
TLDR
The crystal structure of rat endophilin‐A1 BAR domain is solved and a distinctive insert protruding from the membrane interaction face is examined, predicted to form an additional amphipathic helix and important for curvature generation.
A structural explanation for the recognition of tyrosine-based endocytotic signals.
TLDR
Crystal structures of the internalization signal binding domain of mu2 complexed with theinternalization signal peptides of epidermal growth factor receptor and the trans-Golgi network protein TGN38 have been determined at 2.7 angstrom resolution.
Adaptors for clathrin coats: structure and function.
TLDR
The structure of clathrin adaptors is reviewed to establish the dynamic regulatable networks to drive vesicle genesis at the correct time and place in the cell.
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