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Overview of the CCP4 suite and current developments
TLDR
An overview of the CCP4 software suite for macromolecular crystallography is given. Expand
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Scaling and assessment of data quality.
  • P. Evans
  • Mathematics, Medicine
  • Acta crystallographica. Section D, Biological…
  • 2006
The various physical factors affecting measured diffraction intensities are discussed, as are the scaling models which may be used to put the data on a consistent scale. After scaling, theExpand
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How good are my data and what is the resolution?
  • P. Evans, G. Murshudov
  • Computer Science, Medicine
  • Acta crystallographica. Section D, Biological…
  • 13 June 2013
TLDR
The new scaling program AIMLESS is described and tests of refinements at different resolutions are compared with analyses from the scaling step. Expand
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BAR Domains as Sensors of Membrane Curvature: The Amphiphysin BAR Structure
The BAR (Bin/amphiphysin/Rvs) domain is the most conserved feature in amphiphysins from yeast to human and is also found in endophilins and nadrins. We solved the structure of the DrosophilaExpand
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An introduction to data reduction: space-group determination, scaling and intensity statistics
  • P. Evans
  • Computer Science, Medicine
  • Acta crystallographica. Section D, Biological…
  • 18 March 2011
TLDR
A summary of how to run the data-reduction programs in the CCP4 suite. Expand
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Curvature of clathrin-coated pits driven by epsin
Clathrin-mediated endocytosis involves cargo selection and membrane budding into vesicles with the aid of a protein coat. Formation of invaginated pits on the plasma membrane and subsequent buddingExpand
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Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes.
Adaptor protein 180 (AP180) and its homolog, clathrin assembly lymphoid myeloid leukemia protein (CALM), are closely related proteins that play important roles in clathrin-mediated endocytosis. Here,Expand
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Crystal structure at 1.92 Å resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin
The crystal structure of the RNA-binding domain of the small nuclear ribonucleoprotein U1A bound to a 21-nucleotide RNA hairpin has been determined at 1.92 Å resolution. The ten-nucleotide RNA loopExpand
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Molecular Architecture and Functional Model of the Endocytic AP2 Complex
AP2 is the best-characterized member of the family of heterotetrameric clathrin adaptor complexes that play pivotal roles in many vesicle trafficking pathways within the cell. AP2 functions inExpand
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A Large-Scale Conformational Change Couples Membrane Recruitment to Cargo Binding in the AP2 Clathrin Adaptor Complex
Summary The AP2 adaptor complex (α, β2, σ2, and μ2 subunits) crosslinks the endocytic clathrin scaffold to PtdIns4,5P2-containing membranes and transmembrane protein cargo. In the “locked” cytosolicExpand
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