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Neurogenesis in the adult human hippocampus
It is demonstrated that new neurons, as defined by these markers, are generated from dividing progenitor cells in the dentate gyrus of adult humans, indicating that the human hippocampus retains its ability to generate neurons throughout life.
Enriched environment increases neurogenesis in the adult rat dentate gyrus and improves spatial memory.
- M. Nilsson, E. Perfilieva, U. Johansson, O. Orwar, P. Eriksson
- Biology, PsychologyJournal of neurobiology
- 15 June 1999
It is shown that adult rats housed in an enriched environment show improved performance in a spatial learning test, suggesting that environmental cues can enhance neurogenesis in the adult hippocampal region, which is associated with improved spatial memory.
Peripheral Infusion of IGF-I Selectively Induces Neurogenesis in the Adult Rat Hippocampus
- Maria A. I. Åberg, N. Åberg, Helena Hedbäcker, J. Oscarsson, P. Eriksson
- BiologyThe Journal of Neuroscience
- 15 April 2000
Investigation of the effect of the peripheral administration of IGF-I on cellular proliferation in the dentate subgranular proliferative zone of the hippocampus and on the subsequent migration and differentiation of progenitor cells within the GCL shows that peripheral infusion of insulin-like growth factor-I increases progensitor cell proliferation and selectively induces neurogenesis in the progeny of adult neural progenitors.
Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension
The presence of a human RMS is demonstrated, which is unexpectedly organized around a lateral ventricular extension reaching the OB, and the neuroblasts in it are illustrated.
Glucose-Dependent Insulinotropic Polypeptide Is Expressed in Adult Hippocampus and Induces Progenitor Cell Proliferation
Exogenously delivered GIP induced proliferation of adult-derived hippocampal progenitors in vivo as well as in vitro, and adult GIP receptor knock-out mice exhibit a significantly lower number of newborn cells in the hippocampal DG compared with wild-type mice.
IGF-I has a direct proliferative effect in adult hippocampal progenitor cells
Transplantation of Human Embryonic Stem Cell‐Derived Cells to a Rat Model of Parkinson's Disease: Effect of In Vitro Differentiation on Graft Survival and Teratoma Formation
Investigation of the effect of in vitro predifferentiation on in vivo survival and differentiation of hESCs implanted into the 6‐OHDA (6‐hydroxydopamine)‐lesion rat model of PD indicates that prolonged in vitro differentiation ofhESCs is essential for preventing formation of teratomas.
Human embryonic stem cell-derived mesenchymal progenitors--potential in regenerative medicine.
Astrocytes and Stroke: Networking for Survival?
- Michelle F. Anderson, F. Blomstrand, C. Blomstrand, P. Eriksson, M. Nilsson
- BiologyNeurochemical Research
- 1 February 2003
A detailed understanding of the astrocytic response, as well as the timing and location of the changes, is necessary to develop effective treatment strategies for stroke patients.