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Dietary fats and membrane function: implications for metabolism and disease
The understanding of dietary lipid profile and its influence on membrane function in relation to metabolic dysregulation has exciting potential for the prevention and treatment of a range of prevalent disease states. Expand
Mechanisms underlying the cost of living in animals.
The potential importance of membrane acyl composition in metabolic depression, hormonal control of metabolism, the evolution of endothermy, as well as its implications for lifespan and human health, are briefly discussed. Expand
Membranes as possible pacemakers of metabolism.
It is suggested that membranes can act as pacemakers for overall metabolic activity and a possible mechanistic basis for this effect is based on a greater transfer of energy during intermolecular collisions of membrane proteins with the unsaturated two carbon units compared to the single carbon units of saturated acyl chains. Expand
Evolution of energy metabolism. Proton permeability of the inner membrane of liver mitochondria is greater in a mammal than in a reptile.
Standard metabolic rate is 7-fold greater in the rat (a typical mammal) than in the bearded dragon, Amphibolurus vitticeps (a reptile with the same body mass and temperature). Rat hepatocytes respireExpand
Proton conductance and fatty acyl composition of liver mitochondria correlates with body mass in birds.
Mitochondrial proton conductance in liver mitochondria from birds correlated strongly with body mass, suggesting a general relationship between body mass and proton Conductance in endotherms. Expand
Acyl composition of muscle membranes varies with body size in birds.
Allometric variation in the acyl composition of bird muscle phospholipids is similar to that observed in mammals, although birds have fewer n-3 polyunaturates and more n-6 polyunsaturates than do mammalian phospholIPids. Expand
Membranes and the setting of energy demand
The `membrane pacemaker' theory of metabolism proposes that highly polyunsaturated membranes have distinctive physical properties that cause the proteins in the membranes to have a high molecular activity, and this results in higher rates of metabolism of cells, tissues and, consequently, the whole animal. Expand
Fatty acid composition of membrane bilayers: importance of diet polyunsaturated fat balance.
It is shown that the balance of diet n-3 and n-6 polyunsaturated fatty acids (PUFA) is the most important determinant of membrane composition in the rat under 'normal' conditions and this will likely have significant health implications. Expand
Basal Metabolic Rate: History, Composition, Regulation, and Usefulness
  • A. Hulbert, P. Else
  • Biology, Medicine
  • Physiological and Biochemical Zoology
  • 1 November 2004
It is suggested that in different‐sized mammals, the secretion/production of thyroid hormones is a result of BMR differences rather than their cause, and BMR is a useful concept in some situations but not in others. Expand
How might you compare mitochondria from different tissues and different species?
The molecular activity of mitochondrial cytochromes was found to be significantly positively correlated with the relative polyunsaturation of mitochondrial membrane lipids and the turnover of cyto Chromes was calculated and found to vary between 1 and 94 electrons s−1. Expand