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Meta-analysis of acute lung injury and acute respiratory distress syndrome trials testing low tidal volumes.
TLDR
There is a significant difference in the effects of low tidal volume on survival among the five trials, and a meta-analysis demonstrates that significant differences in the control arms can account for the discrepant results among these five trials.
Risk and the efficacy of antiinflammatory agents: retrospective and confirmatory studies of sepsis.
TLDR
The efficacy of antiinflammatory agents during sepsis is dependent on the risk of death, an observation that explains the apparent contradiction between preclinical and clinical trial results.
Risks and benefits of activated protein C treatment for severe sepsis.
A new hypothesis with implications for the treatment of sepsis has recently been tested — the hypothesis that part of the pathophysiology of sepsis is caused by unrestricted or inappropriate coagul...
The effects of steroids during sepsis depend on dose and severity of illness: an updated meta-analysis.
TLDR
Low-dose steroids appear to improve mortality rates in patients with septic shock who are at high risk of death; however, additional trials in this subpopulation are necessary to definitively determine the role of low- dose steroids during sepsis.
Bundled care for septic shock: An analysis of clinical trials*
TLDR
Bundle use was associated with consistent and significant improvement in survival and antibiotic use, and use of other bundle components changed heterogeneously across studies, making their impact on survival uncertain.
Meta-Analysis: The Effect of Steroids on Survival and Shock during Sepsis Depends on the Dose
TLDR
Recent clinical trials with previous clinical trials of steroid use in patients with sepsis are compared to determine whether administering glucocorticoids in dosages similar to the amount produced physiologically during a stressful state affects outcome in septic patients.
Selected Treatment Strategies for Septic Shock Based on Proposed Mechanisms of Pathogenesis
TLDR
The discussants in this conference review several of these new therapies that are directed at different elements of the inflammatory cascade, including a bacterial toxin (endotoxin), host proteins that mediate the inflammatory response (TNF and IL-1), an inflammatory cell (the neutrophil), and a low-molecular-weight messenger (nitric oxide) that causes hypotension.
Surviving sepsis--practice guidelines, marketing campaigns, and Eli Lilly.
TLDR
The development of guidelines for the treatment of sepsis was orchestrated as an extension of a pharmaceutical marketing campaign that appears to have usurped guideline development for commercial purposes, possibly compromising medical quality in the process.
Novel therapies for sepsis: a review.
BACKGROUND Over the past 30 years, efforts have been made to identify therapeutic targets in the host response to infection. METHODS A review of the randomized controlled clinical sepsis trials and
Lethality during continuous anthrax lethal toxin infusion is associated with circulatory shock but not inflammatory cytokine or nitric oxide release in rats.
TLDR
In contrast to LPS, excessive inflammatory cytokine and NO release does not appear to contribute to the circulatory shock and lethality occurring with LeTx in this at model.
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