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Persistent inflammation and immunosuppression: A common syndrome and new horizon for surgical intensive care
ABSTRACT Surgical intensive care unit (ICU) stay of longer than 10 days is often described by the experienced intensivist as a “complicated clinical course” and is frequently attributed to persistentExpand
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A Paradoxical Role for Myeloid-Derived Suppressor Cells in Sepsis and Trauma
Myeloid-derived suppressor cells (MDSCs) are a heterogenous population of immature myeloid cells whose numbers dramatically increase in chronic and acute inflammatory diseases, including cancer,Expand
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Cecal Ligation and Puncture
The cecum contains a high concentration of microbes, which are a combination of Gram‐negative and Gram‐positive flora. These bacteria range from anaerobic to facultative aerobic to aerobic organisms.Expand
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The outcome of sepsis and septic shock has not significantly improved in recent decades despite the development of numerous drugs and supportive care therapies. To reduce sepsis-related mortality, aExpand
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Sepsis Pathophysiology, Chronic Critical Illness, and Persistent Inflammation-Immunosuppression and Catabolism Syndrome
Objectives: To provide an appraisal of the evolving paradigms in the pathophysiology of sepsis and propose the evolution of a new phenotype of critically ill patients, its potential underlyingExpand
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Nitric oxide, an autocrine regulator of wound fibroblast synthetic function.
Nitric oxide (NO) is synthesized in wounds, but its exact role and cellular source are not known. Wound fibroblasts (WF) are phenotypically characterized by increased collagen synthesis andExpand
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Cytokines and wound healing: the role of cytokine and anticytokine therapy in the repair response.
Wound healing is an integrated and complex process involving a large number of regulatory molecules, including proinflammatory cytokines and growth factors, and an orchestrated tissue response.Expand
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Characterization of the Systemic Loss of Dendritic Cells in Murine Lymph Nodes During Polymicrobial Sepsis12
Dendritic cells (DCs) play a key role in critical illness and are depleted in spleens from septic patients and mice. To date, few studies have characterized the systemic effect of sepsis on DCExpand
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Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma
BACKGROUND We recently proffered that a new syndrome persistent inflammation, immunosuppression, and catabolism syndrome (PICS) has replaced late multiple-organ failure as a predominant phenotype ofExpand
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Neutrophil Mobilization from the Bone Marrow during Polymicrobial Sepsis Is Dependent on CXCL12 Signaling
Neutrophils are essential for successful host eradication of bacterial pathogens and for survival to polymicrobial sepsis. During inflammation, the bone marrow provides a large reserve of neutrophilsExpand
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