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Triton-induced hyperlipidemia in rats as an animal model for screening hypolipidemic drugs
We describe a screening test for hypolipidemic agents in which compounds are administered orally to fasted rats after a single intravenous injection of 225 mg Triton WR-1339/kg and serum cholesterolExpand
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Composition and preparation of experimental intravenous fat emulsions.
SUMMARY Components andproceduresusedtoprepareintravenousfatemulsionsforanimalexperiments aredescribed.Thesearecxemplifled bydetailsformakingtheemulsions containing7,12-dimethylbenz(a)anthraceneExpand
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High volume screening procedures for hypobetalipoproteinemic activity in rats.
We describe high volume screening tests for hypobetalipoproteinemic agents in which compounds are administered orally to cholesterol-cholic acid fed (hypercholesterolemic( or normally fed weanlingExpand
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Animal models for an integrated approach to the pharmacologic control of atherosclerosis.
A system of animal models potentially useful for the discovery and evaluation of new effective antiatherosclerotic agents is described. The models consist of a series of lipoprotein andExpand
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Utility of selected line (SEA) of the Japanese quail (Coturnix coturnix japonica) for the discovery of new anti-atherosclerosis drugs.
A special line of the Japanese quail (Coturnix coturnix japonica) was developed by selective breeding to screen for new drugs that are effective in either preventing or reversing atherosclerosis. ByExpand
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Hypo-beta-lipoproteinemic agents. 1. Bicyclo[2.2.2]octyloxyaniline and its derivatives.
A new assay for agents which normalize beta-lipoproteins in cholesterol-cholic acid fed rats is described. Both lowering of serum cholesterol and of serum heparin precipitable lipoproteins (HPL) wereExpand
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Biological activity of a hypobetalipoproteinemic agent.
A new -ind of pharmacologic activity called hypobetalipoproteinemia is described. Iperationally the activity consists of a marked reduction of heparin precipitating lipoproteins (beta and/or pre-betaExpand
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Activity of ethyl 5-(p-chlorophenoxy)-3-hydroxy-3-methylpentanoate, a new hypocholesterolemic compound, in male rats and SEA Japanese quail.
Ethyl 5-(p-chlorophenoxy)-3-hydroxy-3-methylpentanoate (HMP), a new hypocholesterolemic compound, was evaluated in male rats at dosage levels ranging from 25-800 mg/kg/day and in SEA Japanese quailExpand
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Evaluation of timefurone, a new anti-atherosclerotic drug, for its effects on lipoprotein cholesterol in male SEA Japanese quail and rats.
Timefurone was evaluated in several animal models for cholesterol-lowering and anti-atherosclerotic activity. In normal male rats, a dose-response study with timefurone (3, 10, 30, 50 and 100Expand
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