The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.
- L. de Lecea, T. Kilduff, J. Sutcliffe
- BiologyProceedings of the National Academy of Sciences…
- 6 January 1998
A hypothalamus-specific mRNA is described that encodes preprohypocretin, the putative precursor of a pair of peptides that share substantial amino acid identities with the gut hormone secretin, suggesting that the hypocretins function within the CNS as neurotransmitters.
A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms
- T. Lovenberg, B. M. Baron, M. Erlander
- 1 September 1993
Rhes: A striatal‐specific Ras homolog related to Dexras1
- J. Falk, P. Vargiu, J. Sutcliffe
- BiologyJournal of Neuroscience Research
- 15 September 1999
An apparently full‐length cDNA corresponding to a rat mRNA, SE6C, previously identified by subtractive hybridization as being expressed predominantly in the striatal region of the brain is characterized, selecting the name Rhes, for Ras homolog enriched in striatum.
Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain.
- M. Erlander, T. Lovenberg, K. Cannon
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 15 April 1993
Two serotonin (5-hydroxytryptamine, 5-HT) receptors, MR22 and REC17, that belong to the G-protein-associated receptor superfamily are reported and it is proposed that REC17 and MR22 represent a distinct subfamily of 5- HT receptors.
Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin.
- L. de Lecea, P. Ruiz‐Lozano, J. Sutcliffe
- 15 June 1997
Analysis of the nucleotide and predicted amino acid sequences from rat and mouse reveals that the 14 C-terminal residues of preprocortistatin, which make up the sequence that is most similar to somatostatin, are conserved between species.
TOGA: an automated parsing technology for analyzing expression of nearly all genes.
- J. Sutcliffe, P. E. Foye, K. Hasel
- Biology, Computer ScienceProceedings of the National Academy of Sciences…
- 29 February 2000
An automated, high-throughput, systematic cDNA display method called TOGA, an acronym for total gene expression analysis, which allows the status of each mRNA to be compared among samples and its identity to be matched with sequences of known mRNAs compiled in databases.
Insulin receptor substrate protein p53 localization in rats suggests mechanism for specific polyglutamine neurodegeneration
- E. Thomas, P. E. Foye, C. E. Alvarez, H. Usui, J. Sutcliffe
- BiologyNeuroscience Letters
- 31 August 2001
A novel mRNA expressed along brain ventricles.
- P. Danielson, Lauren N Sautkulis, P. E. Foye, P. Hedlund, M. Carson
- BiologyBrain research. Gene expression patterns
Induction of Golli-MBP Expression in CNS Macrophages During Acute LPS-Induced CNS Inflammation and Experimental Autoimmune Encephalomyelitis (EAE)
- T. Papenfuss, J. Thrash, M. Carson
- 2 November 2007
In situ hybridization analysis of LPS/IFNg and experimental autoimmune encephalomyelitis–induced CNS inflammation revealed that only a subset of CNS macrophages express Golli-MBP, consistent with the emerging picture that the phenotype of CNSmacrophages is actively defined by their molecular interactions with the CNS microenvironment.
PCR-Based Technologies to Study Differential Gene Expression in Rat Brain
- M. Erlander, A. Dopazo, P. E. Foye, J. Sutcliffe
It is proposed that a PCR-based differential display methodology which is digital, portable, systematic, quantitative and database-friendly is required to reach the ambitious objective of cloning/identifying virtually all mammalian brain mRNAs.