P. Dyck

Publications738
h-index105
Citations39,833
Highly Influential Citations982
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Diabetic Neuropathies: Update on Definitions, Diagnostic Criteria, Estimation of Severity, and Treatments
Preceding the joint meeting of the 19th annual Diabetic Neuropathy Study Group of the European Association for the Study of Diabetes (NEURODIAB) and the 8th International Symposium on Diabetic… Expand
Human diabetic endoneurial sorbitol, fructose, and myo‐inositol related to sural nerve morphometry
TLDR
A comparison of scored symptoms and signs and clinical neurophysiological studies against morphometric and teased fiber studies of sural nerve demonstrated that the former three provide sensitive and reliable measures of severity of neuropathy that can be used for controlled clinical trials of diabetic neuropathy. Expand
The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population‐based cohort
TLDR
Two thirds of diabetic patients have objective evidence for some variety of neuropathy, but only about 20% have symptoms, and only 6% of IDDM and only 1% of NIDDM patients have sufficiently severe polyneuropathy to be graded stage 2b, and none were graded stage 3. Expand
Chronic inflammatory polyradiculoneuropathy.
The diagnostic criteria, natural history, nerve conduction characteristics, pathology, laboratory features, and efficacy of corticosteroid treatment have been evaluated personally in 53 patients with… Expand
Detection, characterization, and staging of polyneuropathy: Assessed in diabetics
  • P. Dyck
  • Medicine
  • Muscle & nerve
  • 1 January 1988
TLDR
Staging approaches to staging severity of neuropathy should be developed and used in expressing abnormality and minimal criteria for the diagnosis of diabetic polyneuropathy have been proposed and validated tests to assess neuropathic symptoms and sensory deficits have been developed. Expand
Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss
TLDR
These mutations cause premature degradation of mutant proteins, reduced methyltransferase activity and impaired heterochromatin binding during the G2 cell cycle phase leading to global hypomethylation and site-specific hypermethylation. Expand
Quantitative sudomotor axon reflex test in normal and neuropathic subjects
TLDR
Postganglionic sweat output in human subjects resulting from axon reflex stimulation using acetylcholine electrophoresis is quantified using an acrylic plastic chamber placed over a defined area of skin. Expand
Natural history of brachial plexus neuropathy. Report on 99 patients.
TLDR
These studies support the contention that this form of neuropathy is a clinical entity with, in most cases, a fairly typical pattern of symptoms and signs and the overall prognosis is excellent despite the severity and extent of the lesion. Expand
A plasma exchange versus immune globulin infusion trial in chronic inflammatory demyelinating polyradiculoneuropathy
TLDR
Both treatments are efficacious in ameliorating neurological deficit in chronic inflammatory demyelinating polyradiculoneuropathy and the frequency and dosage needed to maintain good function could be titrated by assessing the neurological disability score and the summated muscle action potentials at 6‐week intervals. Expand
Oral Treatment With α-Lipoic Acid Improves Symptomatic Diabetic Polyneuropathy
TLDR
Oral treatment with ALA for 5 weeks improved neuropathic symptoms and deficits in patients with DSP and an oral dose of 600 mg once daily appears to provide the optimum risk-to-benefit ratio. Expand
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