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Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension.
TLDR
Increased serum levels of IL-1 beta and IL-6 in severe PPH are demonstrated, and a role for proinflammatory cytokines in PPH is suggested, and it is suggested that COPD-PH patients with pulmonary hypertension secondary to chronic obstructive pulmonary disease should be considered for lung transplantation. Expand
Severe pulmonary hypertension in histiocytosis X.
TLDR
Results indicate that pulmonary hypertension in pulmonary histiocytosis X might be related to an intrinsic pulmonary vascular disease, in which the pulmonary circulation is involved independent of small airway and lung parenchyma injury. Expand
Pulmonary vascular disorders in portal hypertension.
TLDR
The severity of hepatopulmonary syndrome seems to parallel the severity of liver failure, whereas no simple relationship has been identified between hepatic impairment and the severity in portopul pulmonary hypertension. Expand
Platelet-derived growth factor expression in primary pulmonary hypertension: comparison of HIV seropositive and HIV seronegative patients.
TLDR
A possible role for PDGF in PPH occurring in HIV seropositive and seronegative patients is documented and growth factors such as platelet-derived growth factor may play a part in the initiation and/or progression of primary pulmonary hypertension. Expand
Increased plasma serotonin in primary pulmonary hypertension.
TLDR
The persistent decrease in platelet storage of serotonin after heart-lung transplantation suggests that this platelet abnormality is not secondary to PPH, and normal handling of serotonin by platelets leading to an increase in plasma serotonin occurs in PPH. Expand
Comparison of nebulized budesonide and oral prednisolone with placebo in the treatment of acute exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial.
TLDR
Nebulized budesonide may be an alternative to oral prednisolone in the treatment of nonacidotic exacerbations of COPD but further studies should be done to evaluate its long-term impact on clinical outcomes after an initial episode of COPd exacerbation. Expand
Pulmonary artery pulse pressure and wave reflection in chronic pulmonary thromboembolism and primary pulmonary hypertension.
TLDR
CPTE and PPH with severe pulmonary hypertension had similar PA pulse pressure, and wave reflection is elevated in both groups, and CPTE had increased and anticipated wave reflection as compared with PPH, thus suggesting differences in the pulsatile component of right ventricular afterload. Expand
Primary pulmonary hypertension and fenfluramine use.
TLDR
The results do not accord with earlier reports that PPH associated with fenfluramine is less severe and has a better outcome, and the results of a European case-control study should give new insights into risk factors for PPH and the cause and effect relation with fENFLuramine. Expand
Intraesophageal perfusion of acid increases the bronchomotor response to methacholine and to isocapnic hyperventilation in asthmatic subjects.
TLDR
Perfusion of acid into the distal esophagus caused slight but significant bronchoconstriction in asthmatic subjects with GER and increased the bronchconstriction produced by isocapnic hyperventilation and by methacholine in astHmatic subjects without regard for the presence of GER. Expand
Factors Influencing Pulmonary Volumes and CO2 Elimination during High‐frequency Jet Ventilation
TLDR
The results suggest that HFJV should not be used in patients with chronic obstructive pulmonary disease and asthma, and should be preferentially administered to patients having stiff lungs or decreased chest wall compliance. Expand
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