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The Formation of Biofilms by Pseudomonas aeruginosa: A Review of the Natural and Synthetic Compounds Interfering with Control Mechanisms
TLDR
The objective of this report is to provide an overview of the main key actors relevant in the regulation of biofilm formation by P. aeruginosa and to consider biofilm lifestyle as a target for eradication of resistant infections caused by the bacterium.
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Statistics of the Comet assay: a key to discriminate between genotoxic effects.
TLDR
It is concluded that a trend analysis of median comet metrics from repeated experiments at different stress levels is certainly an efficient way to statistically demonstrate a genotoxic effect.
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Pharmacovigilance practice and risk control of Traditional Chinese Medicine drugs in China: current status and future perspective.
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Effect of oral creatine supplementation on urinary methylamine, formaldehyde, and formate.
TLDR
This investigation shows that short-term, high-dose oral creatine supplementation enhances the excretion of potential cytotoxic compounds, but does not have any detrimental effects on kidney permeability, providing indirect evidence of the absence of microangiopathy in renal glomeruli.
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Homoisoflavanones from Disporopsis aspera.
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The flavanone naringenin reduces the production of quorum sensing-controlled virulence factors in Pseudomonas aeruginosa PAO1.
Preliminary screening of the Malagasy plant Combretum albiflorum for compounds attenuating the production of quorum sensing (QS)-controlled virulence factors in bacteria led to the identification of…
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The quest for modernisation of traditional Chinese medicine
TLDR
This narrative review aims to summarise the findings of the FP7 GP-TCM project, highlight the scientific evidence behind TCM, update the most important milestones and pitfalls, and propose integrity, integration and innovation as key principles for further modernisation of TCM.
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Cytotoxic constituents from Plumbago zeylanica.
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Metabolic, nutritional, iatrogenic, and artifactual sources of urinary organic acids: a comprehensive table.
TLDR
This table is intended to assist in the interpretation of organic acid profiles because, in addition to IEM, it also refers to other pathologic causes and to physiologic, nutritional, iatrogenic, and artifactual sources.
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Balanitin-6 and -7: diosgenyl saponins isolated from Balanites aegyptiaca Del. display significant anti-tumor activity in vitro and in vivo.
TLDR
Preliminary in vivo data suggest that it may be possible to generate novel hemi-synthetic derivatives of balanitin-6 and -7 with potentially improved in vitro and in vivo anti-cancer activity and reduced in vivo toxicity, thus markedly improving the therapeutic ratio.
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