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Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein
TLDR
Mgp, a mineral-binding ECM protein3 synthesized by vascular smooth-muscle cells and chondrocytes, is the first inhibitor of calcification of arteries and cartilage to be characterized in vivo.
Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice
TLDR
It is shown that long-term treatment of WT mice with osteocalcin can significantly weaken the deleterious effect on body mass and glucose metabolism of gold thioglucose-induced hyperphagia and high-fat diet and suggest that osteocalin may be of value in the treatment of metabolic diseases.
Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene
TLDR
It is demonstrated that two distinct cis-acting elements are responsible for osteoblast expression of mouse osteocalcin gene 2 and provides for the first time a functional characterization of osteooblast-specific cis- acting elements.
Increased bone formation in osteocalcin-deficient mice
TLDR
This study provides the first evidence that osteocalcin is a determinant of bone formation, and generates osteocalin-deficient mice that develop a phenotype marked by higher bone mass and bones of improved functional quality.
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