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Time course of the development of motor behaviors in the zebrafish embryo.
The development and properties of locomotor behaviors in zebrafish embryos raised at 28.5 degrees C were examined. When freed from the chorion, embryonic zebrafish showed three sequential stereotypedExpand
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Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo.
TDP-43 has been found in inclusion bodies of multiple neurological disorders, including amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease and Alzheimer's disease. MutationsExpand
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Novel de novo SHANK3 mutation in autistic patients
A number of studies have confirmed that genetic factors play an important role in autism spectrum disorder (ASD). More recently de novo mutations in the SHANK3 gene, a synaptic scaffolding protein,Expand
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Synaptic drive to motoneurons during fictive swimming in the developing zebrafish.
The development of swimming behavior and the correlated activity patterns recorded in motoneurons during fictive swimming in paralyzed zebrafish larvae were examined and compared. Larvae were studiedExpand
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Mutations in the KIAA0196 gene at the SPG8 locus cause hereditary spastic paraplegia.
Hereditary spastic paraplegia (HSP) is a progressive upper-motor neurodegenerative disease. The eighth HSP locus, SPG8, is on chromosome 8p24.13. The three families previously linked to the SPG8Expand
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Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia
Growing genetic evidence is converging in favor of common pathogenic mechanisms for autism spectrum disorders (ASD), intellectual disability (ID or mental retardation) and schizophrenia (SCZ), threeExpand
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Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia
Autism spectrum disorder (ASD) and schizophrenia (SCZ) are two common neurodevelopmental syndromes that result from the combined effects of environmental and genetic factors. We set out to test theExpand
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LANDSCAPE-SCALE DISTURBANCES AND CHANGES IN BIRD COMMUNITIES OF BOREAL MIXED-WOOD FORESTS
Bird community response to both landscape-scale and local (forest types) changes in forest cover was studied in three boreal mixed-wood forest landscapes modified by different types of disturbances:Expand
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Development of the locomotor network in zebrafish
The zebrafish is a leading model for studies of vertebrate development and genetics. Its embryonic motor behaviors are easy to assess (e.g. for mutagenic screens), the embryos develop rapidlyExpand
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Mutations in VANGL1 associated with neural-tube defects.
Neural-tube defects such as anencephaly and spina bifida constitute a group of common congenital malformations caused by complex genetic and environmental factors. We have identified three mutationsExpand
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