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- Publications
- Influence
Time course of the development of motor behaviors in the zebrafish embryo.
- L. Saint-Amant, P. Drapeau
- Biology, Medicine
- Journal of neurobiology
- 1 December 1998
The development and properties of locomotor behaviors in zebrafish embryos raised at 28.5 degrees C were examined. When freed from the chorion, embryonic zebrafish showed three sequential stereotyped… Expand
Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo.
- E. Kabashi, L. Lin, +9 authors P. Drapeau
- Biology, Medicine
- Human molecular genetics
- 15 February 2010
TDP-43 has been found in inclusion bodies of multiple neurological disorders, including amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease and Alzheimer's disease. Mutations… Expand
Novel de novo SHANK3 mutation in autistic patients
- J. Gauthier, D. Spiegelman, +12 authors G. Rouleau
- Biology, Medicine
- American journal of medical genetics. Part B…
- 5 April 2009
A number of studies have confirmed that genetic factors play an important role in autism spectrum disorder (ASD). More recently de novo mutations in the SHANK3 gene, a synaptic scaffolding protein,… Expand
Synaptic drive to motoneurons during fictive swimming in the developing zebrafish.
- R. Buss, P. Drapeau
- Biology, Medicine
- Journal of neurophysiology
- 1 July 2001
The development of swimming behavior and the correlated activity patterns recorded in motoneurons during fictive swimming in paralyzed zebrafish larvae were examined and compared. Larvae were studied… Expand
Mutations in the KIAA0196 gene at the SPG8 locus cause hereditary spastic paraplegia.
- P. Valdmanis, I. Meijer, +8 authors G. Rouleau
- Biology, Medicine
- American journal of human genetics
- 2007
Hereditary spastic paraplegia (HSP) is a progressive upper-motor neurodegenerative disease. The eighth HSP locus, SPG8, is on chromosome 8p24.13. The three families previously linked to the SPG8… Expand
Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia
- J. Gauthier, Tabrez J. Siddiqui, +18 authors G. Rouleau
- Biology, Medicine
- Human Genetics
- 22 March 2011
Growing genetic evidence is converging in favor of common pathogenic mechanisms for autism spectrum disorders (ASD), intellectual disability (ID or mental retardation) and schizophrenia (SCZ), three… Expand
Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia
- A. Piton, J. Gauthier, +32 authors G. Rouleau
- Biology, Medicine
- Molecular Psychiatry
- 1 August 2011
Autism spectrum disorder (ASD) and schizophrenia (SCZ) are two common neurodevelopmental syndromes that result from the combined effects of environmental and genetic factors. We set out to test the… Expand
LANDSCAPE-SCALE DISTURBANCES AND CHANGES IN BIRD COMMUNITIES OF BOREAL MIXED-WOOD FORESTS
- P. Drapeau, A. Leduc, J. Giroux, Jean-Pierre L. Savard, Y. Bergeron, W. Vickery
- Geography
- 1 February 2000
Bird community response to both landscape-scale and local (forest types) changes in forest cover was studied in three boreal mixed-wood forest landscapes modified by different types of disturbances:… Expand
Development of the locomotor network in zebrafish
- P. Drapeau, Louis Saint-Amant, R. Buss, Mabel Chong, E. Brustein
- Biology, Medicine
- Progress in Neurobiology
- 1 October 2002
The zebrafish is a leading model for studies of vertebrate development and genetics. Its embryonic motor behaviors are easy to assess (e.g. for mutagenic screens), the embryos develop rapidly… Expand
Mutations in VANGL1 associated with neural-tube defects.
Neural-tube defects such as anencephaly and spina bifida constitute a group of common congenital malformations caused by complex genetic and environmental factors. We have identified three mutations… Expand