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Nerve growth factor contributes to the up-regulation of growth-associated protein 43 and preprotachykinin a messenger RNAs in primary sensory neurons following peripheral inflammation
Peripheral inflammation induced in adult rats by an intraplantar injection of complete Freund's adjuvant results in a rapid (6 h) increase in the expression of the messenger RNAs for the neuronalExpand
Increased innervation of the vulval vestibule in patients with vulvodynia
Summary Background Vulval vestibulitis is a condition characterized by the sudden onset of a painful burning sensation, hyperalgesia, mechanical allodynia, and occasionally pruritus, localized to theExpand
src‐related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular endothelial cells
src‐related cytoplasmic PTKs are physically and functionally associated with cell surface receptors and are involved in signal transduction. In this paper we report the identification of src‐relatedExpand
Inhibitors of nitric oxide synthase in human skin.
The aim of this study was to investigate in human skin in vivo the role of nitric oxide in maintaining resting vascular tone, in the vasodilatation caused by local warming and by ultraviolet B lightExpand
The release of leukotriene B4-like material in biologically active amounts from the lesional skin of patients with psoriasis.
The 5,12-dihydroxy metabolite of arachidonic acid, leukotriene B4, is a highly potent neutrophil chemoattractant. In view of the characteristic epidermal neutrophil infiltrate in psoriasis, theExpand
Increased vanilloid receptor VR1 innervation in vulvodynia
Vulvodynia is characterised by painful burning sensation, allodynia and hyperalgesia in the region of the vulval vestibulus. While in many patients the cause of vulvodynia remains uncertain, we andExpand
Hypersensitivity in aseptic loosening of total hip replacements. The role of constituents of bone cement.
Aseptic loosening is seen in a significant proportion of cemented total hip replacements (THR). In a small subgroup of patients who suffer early loosening polyethylene debris is unlikely to beExpand
The treatment of chilblains with nifedipine: the results of a pilot study, a double‐blind placebo‐controlled randomized study and a long‐term open trial
A pilot study, a double‐blind placebo‐controlled randomised study and a long term open trial have indicated that nifedipine is effective in the treatment of perniosis. At a dose of 20 mg to 60 mgExpand
Nifedipine in the treatment of chilblains.
Treatment of Raynaud's phenomenon by intravenous infusion of prostacyclin (PGI2)
Twenty five patients with Raynaud's phenomenon due to systemic sclerosis were infused with prostacyclin (PGI2). In 88% of the patients there was objective improvement, monitored by thermography orExpand