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Inference of population structure using multilocus genotype data.
We describe a model-based clustering method for using multilocus genotype data to infer population structure and assign individuals to populations. We assume a model in which there are K populations… Expand
A new statistical method for haplotype reconstruction from population data.
Current routine genotyping methods typically do not provide haplotype information, which is essential for many analyses of fine-scale molecular-genetics data. Haplotypes can be obtained, at… Expand
A comparison of bayesian methods for haplotype reconstruction from population genotype data.
In this report, we compare and contrast three previously published Bayesian methods for inferring haplotypes from genotype data in a population sample. Expand
Association mapping in structured populations.
- J. Pritchard, M. Stephens, N. Rosenberg, P. Donnelly
- Biology, Medicine
- American journal of human genetics
- 1 July 2000
The use, in association studies, of the forthcoming dense genomewide collection of single-nucleotide polymorphisms (SNPs) has been heralded as a potential breakthrough in the study of the genetic… Expand
A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies
Genotype imputation methods are now being widely used in the analysis of genome-wide association studies. Most imputation analyses to date have used the HapMap as a reference dataset, but new… Expand
A new multipoint method for genome-wide association studies by imputation of genotypes
Genome-wide association studies are set to become the method of choice for uncovering the genetic basis of human diseases. A central challenge in this area is the development of powerful multipoint… Expand
A second generation human haplotype map of over 3.1 million SNPs
We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations and… Expand
Transcriptome and genome sequencing uncovers functional variation in humans
Genome sequencing projects are discovering millions of genetic variants in humans, and interpretation of their functional effects is essential for understanding the genetic basis of variation in… Expand
The UK Biobank resource with deep phenotyping and genomic data
The UK Biobank project is a prospective cohort study with deep genetic and phenotypic data collected on approximately 500,000 individuals from across the United Kingdom, aged between 40 and 69 at… Expand
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study… Expand