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The de novo synthesis of ubiquitin: identification of deubiquitinases acting on ubiquitin precursors
TLDR
Data is provided suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Expand
Proteomics of immune-challenged Drosophila melanogaster larvae hemolymph.
TLDR
The aim of this study was to investigate hemolymph proteins differentially expressed between control and immunised larvae sets, which could be related solely to the Drosophila immune response. Expand
The role of salivary peptides in dental caries.
TLDR
A strong correlation between large amounts phosphopeptides (PRP1/3, histatin 1 and statherin), and the absence of dental caries is verified, which reinforces the importance of these peptides in the maintenance of tooth integrity. Expand
Identification of human whole saliva protein components using proteomics
TLDR
The aim of this work was the identification of saliva proteins using proteomics, and 11 proteins that have not been previously identified in saliva, PLUNC, Cystatin A, and cystatin B were identified. Expand
Identification of oxidation products and free radicals of tryptophan by mass spectrometry
TLDR
New oxidation products and free radicals derived from tryptophan (Trp) oxidation under Fenton reaction conditions were identified using mass spectrometry and the proposed structure of the observed adducts was confirmed. Expand
Two-dimensional electrophoresis study of in vitro pellicle formation and dental caries susceptibility.
TLDR
Higher quantities of lipocalin, and cystatins S and SN found in the samples from the caries-free subjects suggest that inhibition of proteolytic events on other salivary proteins may indirectly provide tooth protection. Expand
Oxidation of bovine serum albumin: identification of oxidation products and structural modifications.
TLDR
Results suggest the oxidative damage occurs first in exposed regions near cysteine disulfide bridges with residues like methionine, tryptophan, lysine, arginine, tyrosine and proline appearing as oxidatively modified. Expand
Lipoxidation adducts with peptides and proteins: deleterious modifications or signaling mechanisms?
TLDR
While in many cases lipoxidation interferes with protein function, causing inhibition of enzymatic activity and increased immunogenicity, there are a small number of cases wherelipoxidation results in gain of function or activity. Expand
Fragmentation study of short-chain products derived from oxidation of diacylphosphatidylcholines by electrospray tandem mass spectrometry: identification of novel short-chain products.
TLDR
The detailed knowledge of lipid peroxidation degradation products is of major importance and should be very valuable in providing new markers for oxidative stress signaling and for disease states monitoring. Expand
Peptide profile of human acquired enamel pellicle using MALDI tandem MS.
TLDR
The present study proposes a strategy for human in vivo acquired enamel pellicle (AEP) peptidome characterisation based on sequential extraction with guanidine and TFA followed by MALDI-TOF/TOF identification to suggest that proteolytic activity could influence AEP formation and composition. Expand
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