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The de novo synthesis of ubiquitin: identification of deubiquitinases acting on ubiquitin precursors
- C. Grou, M. P. Pinto, Andreia Mendes, P. Domingues, Jorge E Azevedo
- BiologyScientific reports
- 3 August 2015
Data is provided suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing.
Proteomics of immune-challenged Drosophila melanogaster larvae hemolymph.
Identification of human whole saliva protein components using proteomics
The aim of this work was the identification of saliva proteins using proteomics, and 11 proteins that have not been previously identified in saliva, PLUNC, Cystatin A, and cystatin B were identified.
The role of salivary peptides in dental caries.
- R. Vitorino, M. J. Lobo, José Duarte, A. Ferrer-Correia, P. Domingues, F. Amado
- BiologyBiomedical chromatography : BMC
- 1 April 2005
A strong correlation between large amounts phosphopeptides (PRP1/3, histatin 1 and statherin), and the absence of dental caries is verified, which reinforces the importance of these peptides in the maintenance of tooth integrity.
Post-translational modifications and mass spectrometry detection.
Identification of oxidation products and free radicals of tryptophan by mass spectrometry
Lipoxidation adducts with peptides and proteins: deleterious modifications or signaling mechanisms?
Two-dimensional electrophoresis study of in vitro pellicle formation and dental caries susceptibility.
Higher quantities of lipocalin, and cystatins S and SN found in the samples from the caries-free subjects suggest that inhibition of proteolytic events on other salivary proteins may indirectly provide tooth protection.
Oxidation of bovine serum albumin: identification of oxidation products and structural modifications.
- Sofia Guedes, R. Vitorino, Rosário M. Domingues, F. Amado, P. Domingues
- Biology, ChemistryRapid communications in mass spectrometry : RCM
- 15 August 2009
Results suggest the oxidative damage occurs first in exposed regions near cysteine disulfide bridges with residues like methionine, tryptophan, lysine, arginine, tyrosine and proline appearing as oxidatively modified.