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Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
SIGNAL transducers and activators of transcription (STATs) are activated by tyrosine phosphorylation in response to cytokines and mediate many of their functional responses1–3. Stat4 was initiallyExpand
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Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
SIGNAL transducers and activators of transcription (Stats) are activated by tyrosine phosphorylation in response to cytokines, and are thought to mediate many of their functional responses1–4. Stat6Expand
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Altered peptidase and viral-specific T cell response in LMP2 mutant mice.
MHC class I molecules present peptides generated by processing of endogenously synthesized proteins to CD8+ T lymphocytes. Recently, large proteolytic complexes, termed proteasomes, were implicatedExpand
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Virus-specific CD8+ T cells in primary and secondary influenza pneumonia.
Virus-specific CD8+ effector T cells (eCTL) are enriched in the lungs of mice with primary influenza pneumonia, though later detection of memory T cells (mCTL) in the mediastinal lymph nodes (MLN) orExpand
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CD8+ T cells clear influenza virus by perforin or Fas-dependent processes.
Influenza virus infection is controlled in CD4-depleted mice that are also defective for the expression of either Fas (Fas-/-) or perforin (P-/-). Virus-immune P+/+ and P-/- CD8+ T cells can thusExpand
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The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1.
Virus-induced interlukin-1beta (IL-1beta) and IL-18 production in macrophages are mediated via caspase-1 pathway. Multiple microbial components, including viral RNA, are thought to trigger assemblyExpand
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Cell-mediated Protection in Influenza Infection
Cell-mediated immune responses should be considered in vaccination protocols.
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Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells
A unique experimental model has been developed for dissecting the integrity of CD8+ T cell-mediated immunity to a persistent gammaherpesvirus under conditions of CD4+ T cell deficiency. RespiratoryExpand
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Effector CD4+ and CD8+ T-cell mechanisms in the control of respiratory virus infections.
The rules for T-cell-mediated control of viruses that infect via the respiratory mucosae show both common themes and differences, depending on the nature of the pathogen. Virus-specific CD8+Expand
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MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness.
Publisher Summary This chapter focuses on the important discovery that virus-specific cytotoxic T cells are dually specific for virus and for a self cell surface antigen encoded by the majorExpand
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