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Higher level organization of individual gene transcription and RNA splicing.
Visualization of fibronectin and neurotensin messenger RNAs within mammalian interphase nuclei was achieved by fluorescence hybridization with genomic, complementary DNA, and intron-specific probes.… Expand
Developmental expression and activities of specific fos and jun proteins are functionally related to osteoblast maturation: role of Fra-2 and Jun D during differentiation.
Developmental studies of oncogene expression implicate the Fos and Jun family of transcription factors in the regulation of bone growth and differentiation. Promoters of many developmentally… Expand
Neurotensin and pain modulation
- P. Dobner
- 1 October 2006
Neurotensin (NT) can produce a profound analgesia or enhance pain responses, depending on the circumstances. Recent evidence suggests that this may be due to a dose-dependent recruitment of distinct… Expand
Multitasking with neurotensin in the central nervous system
- P. Dobner
- Biology, Medicine
- Cellular and Molecular Life Sciences CMLS
- 7 July 2005
Abstract.The 13-amino acid peptide neurotensin (NT) was discovered over 30 years ago and has been implicated in a wide variety of neurotransmitter and endocrine functions. This review focuses on four… Expand
An obligatory role for neurotensin in high fat diet-induced obesity
Obesity and its associated comorbidities (for example, diabetes mellitus and hepatic steatosis) contribute to approximately 2.5 million deaths annually and are among the most prevalent and… Expand
Differential effects of haloperidol and clozapine on neurotensin gene transcription in rat neostriatum
- K. Merchant, P. Dobner, D. Dorsa
- Biology, Medicine
- The Journal of neuroscience : the official…
- 1 February 1992
A single dose of typical neuroleptic, haloperidol, has been demonstrated to increase the expression of neurotensin/neuromedin N (NT/N) mRNA in the dorsolateral striatum within 1 hr of its… Expand
Involvement of MAP-kinase, PI3-kinase and EGF-receptor in the stimulatory effect of Neurotensin on DNA synthesis in PC3 cells
The mechanism by which neurotensin (NT) promotes the growth of prostate cancer epithelial cells is not yet defined. Here, androgen-independent PC3 cells, which express high levels of the type 1… Expand
Synergistic activation of neurotensin/neuromedin N gene expression by c-Jun and glucocorticoids: novel effects of Fos family proteins.
The cis-regulatory region of the neurotensin/neuromedin N (NT/N) gene integrates diverse environmental signals in the neuroendocrine PC12 cell line, resulting in remarkable synergistic regulation. An… Expand
Endogenous neurotensin facilitates visceral nociception and is required for stress-induced antinociception in mice and rats
Central neurotensin (NT) administration can both facilitate and inhibit somatic and visceral nociception, depending on the dose and administration site. NT microinjection in the rostroventral medulla… Expand
The rat gene encoding neurotensin and neuromedin N. Structure, tissue-specific expression, and evolution of exon sequences.
- E. Kislauskis, B. Bullock, Sara McNeil, P. Dobner
- Medicine, Biology
- The Journal of biological chemistry
- 5 April 1988
Recombinant DNA clones encoding the neurotensin/neuromedin N precursor protein have been isolated from both bovine hypothalamus cDNA and rat genomic libraries using a heterologous canine cDNA probe.… Expand