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Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan
Although the role of Toll-like receptors in extracellular bacterial sensing has been investigated intensively, intracellular detection of bacteria through Nod molecules remains largelyExpand
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The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation In Vivo
Formation of neuromuscular synapses requires a series of inductive interactions between growing motor axons and differentiating muscle cells, culminating in the precise juxtaposition of a highlyExpand
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Agrin Acts via a MuSK Receptor Complex
Formation of th neuromuscular junction depends upon reciprocal inductive interactions between the developing nerve and muscle, resulting in the precise juxtaposition of a differentiated nerveExpand
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DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein
The signaling pathway from phosphoinositide 3-kinase to the protein kinase Akt controls organismal life-span in invertebrates and cell survival and proliferation in mammals by inhibiting the activityExpand
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Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.
High-throughput screening against the human sirtuin SIRT1 led to the discovery of a series of indoles as potent inhibitors that are selective for SIRT1 over other deacetylases and NAD-processingExpand
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The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases
We report the identification of ligands for Tyro 3 (alternatively called Sky, rse, brt, or tif) and Axl (alternatively, Ark or UFO), members of a previously orphan family of receptor-like tyrosineExpand
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Substrate-specific Activation of Sirtuins by Resveratrol*
Resveratrol, a small molecule found in red wine, is reported to slow aging in simple eukaryotes and has been suggested as a potential calorie restriction mimetic. Resveratrol has also been reportedExpand
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Inhibition of SIRT1 Catalytic Activity Increases p53 Acetylation but Does Not Alter Cell Survival following DNA Damage
ABSTRACT Human SIRT1 is an enzyme that deacetylates the p53 tumor suppressor protein and has been suggested to modulate p53-dependent functions including DNA damage-induced cell death. In thisExpand
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Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation
We have developed an experimental paradigm to study the mechanism by which nerve growth factor (NGF) allows the survival of sympathetic neurons. Dissociated sympathetic neurons from embryonic day-21Expand
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Sodium Channel β4, a New Disulfide-Linked Auxiliary Subunit with Similarity to β2
The principal α subunit of voltage-gated sodium channels is associated with auxiliary β subunits that modify channel function and mediate protein-protein interactions. We have identified a new βExpand
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