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Developing and evaluating complex interventions: the new Medical Research Council guidance
Evaluating complex interventions is complicated. The Medical Research Council's evaluation framework (2000) brought welcome clarity to the task. Now the council has updated its guidance
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Developing and evaluating complex interventions: the new Medical Research Council guidance.
1MRC Population Health Sciences Research Network, Glasgow G12 8RZ; 2Nuffield Department of Orthopaedic Surgery, University of Oxford, Nuffield Orthopaedic Centre, Oxford OX3 7LD; 3MRC Social andExpand
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Developing and Evaluating Complex Interventions: New Guidance
Peter Craig, MRC Population Health Sciences Research Network Paul Dieppe, Nuffield Department of Orthopaedic Surgery, University of Oxford Sally Macintyre, MRC Social and Public Health Sciences UnitExpand
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Osteoarthritis: New Insights. Part 1: The Disease and Its Risk Factors
Osteoarthritis: The Disease and Its Prevalence and Impact Dr. David T. Felson (Boston University School of Medicine, Boston, Massachusetts), Ms. Reva C. Lawrence (National Institute of Arthritis andExpand
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What is successful ageing and who should define it?
The substantial increases in life expectancy at birth achieved over the previous century, combined with medical advances, escalating health and social care costs, and higher expectations for olderExpand
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Pathogenesis and management of pain in osteoarthritis
The term osteoarthritis describes a common, age-related, heterogeneous group of disorders characterised pathologically by focal areas of loss of articular cartilage in synovial joints, associatedExpand
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Complex interventions to improve physical function and maintain independent living in elderly people: a systematic review and meta-analysis
Summary Background In old age, reduction in physical function leads to loss of independence, the need for hospital and long-term nursing-home care, and premature death. We did a systematic review toExpand
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Etiopathogenesis of osteoarthritis.
Because of the implications for prevention and treatment, how a clinician views osteoarthritis (OA) matters. We view OA as an attempt to contain a mechanical problem in the joint and as failed repairExpand
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Risk factors for the incidence and progression of radiographic knee osteoarthritis.
OBJECTIVE Preventive strategies against knee osteoarthritis (OA) require a knowledge of risk factors that influence the initiation of the disorder and its subsequent progression. ThisExpand
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What proportion of patients report long-term pain after total hip or knee replacement for osteoarthritis? A systematic review of prospective studies in unselected patients
Background Total hip or knee replacement is highly successful when judged by prosthesis-related outcomes. However, some people experience long-term pain. Objectives To review published studies inExpand
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