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Tyrosine hydroxylase phosphorylation: regulation and consequences
- P. Dunkley, L. Bobrovskaya, M. Graham, E. V. von Nagy-Felsobuki, P. Dickson
- Biology, ChemistryJournal of neurochemistry
- 1 December 2004
Hierarchical phosphorylation of tyrosine hydroxylase occurs both in vitro and in situ, whereby theosphorylation at Ser19 increases the rate of Ser40 phosphorylated leading to an increase in enzyme activity.
Rat choroid plexus specializes in the synthesis and the secretion of transthyretin (prealbumin). Regulation of transthyretin synthesis in choroid plexus is independent from that in liver.
- P. Dickson, A. Aldred, P. Marley, D. Bannister, G. Schreiber
- BiologyThe Journal of biological chemistry
- 15 March 1986
The pattern of the observed changes in the levels of mRNAs for plasma proteins in the liver was independent of whether the acute inflammation was produced by subcutaneous injection of turpentine or intraperitoneal injection of a suspension of talcum.
Differential Regulation of the Human Tyrosine Hydroxylase Isoforms via Hierarchical Phosphorylation*
- I. Lehmann, L. Bobrovskaya, Sarah L Gordon, P. Dunkley, P. Dickson
- Biology, ChemistryJournal of Biological Chemistry
- 30 June 2006
H hierarchical phosphorylation provides a mechanism whereby the two major human TH isoforms can be differentially regulated with only isoform 1 responding to the ERK pathway, whereas isoform 2 is more sensitive to calcium-mediated events.
Rat transthyretin (prealbumin). Molecular cloning, nucleotide sequence, and gene expression in liver and brain.
Thyroxine transport in choroid plexus.
High prealbumin and transferrin mRNA levels in the choroid plexus of rat brain.
Phosphorylation of Ser19 Alters the Conformation of Tyrosine Hydroxylase to Increase the Rate of Phosphorylation of Ser40 *
- L. Bevilaqua, M. Graham, P. Dunkley, E. V. von Nagy-Felsobuki, P. Dickson
- Chemistry, BiologyThe Journal of Biological Chemistry
- 2 November 2001
It is suggested that phosphorylation of Ser19 alters the conformation of tyrosine hydroxylase to allow increased accessibility of Ser40 to kinases.
Tyrosine hydroxylase: regulation by feedback inhibition and phosphorylation.
Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase.
Phosphorylation of Ser19 increases both Ser40 phosphorylation and enzyme activity of tyrosine hydroxylase in intact cells
These data provide the first evidence that the phosphorylation of Ser19 can potentiate the phosphories of Ser40 and subsequent activation of tyrosine hydroxylase in intact cells.