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Direct Regulation of Adult Brain Function by the Male-Specific Factor SRY
TLDR
It is demonstrated that the Y chromosome-linked, male-determining gene Sry is specifically expressed in the substantia nigra of the adult male rodent in tyrosine hydroxylase-expressing neurons. Expand
Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans.
TLDR
It is shown that, in testicular Sertoli and Leydig cells, Wnt-4 up-regulates Dax1, a gene known to antagonize the testis-determining factor, Sry, which suggests that mammalian sex determination is sensitive to dosage, at multiple steps in its pathway. Expand
Sexually dimorphic gene expression in mouse brain precedes gonadal differentiation.
TLDR
This work has detected over 50 candidate genes for differential sex expression, and confirmed at least seven murine genes which show differential expression between the developing brains of male and female mice at stage 10.5 days post coitum (dpc), before any gonadal hormone influence. Expand
Membrane Estrogen Receptor-α Interactions with Metabotropic Glutamate Receptor 1a Modulate Female Sexual Receptivity in Rats
TLDR
Data is presented that shows that ERα and mGluR1a directly interact to mediate a rapid estradiol-induced activation of MOR in the medial preoptic nucleus, leading to female sexual receptivity, demonstrating the physiological importance of ERα-to-mGlu R1a signaling. Expand
Dimerization of SOX9 is required for chondrogenesis, but not for sex determination.
TLDR
It is established that SOX9 cooperative dimerization is required for chondrogenesis but not for sex determination and may explain why campomelic dysplasia need not be associated with XY sex reversal. Expand
Membrane-Initiated Estradiol Signaling Induces Spinogenesis Required for Female Sexual Receptivity
TLDR
It is demonstrated that estradiol-induced spinogenesis in the ARH is an important cellular mechanism for the regulation of female sexual behavior. Expand
Protein kinase C signaling in the hypothalamic arcuate nucleus regulates sexual receptivity in female rats.
TLDR
Findings indicate that rapid membrane ERalpha-mGluR1a interactions activate PKCtheta cell signaling, which regulates female sexual receptivity. Expand
Membrane-initiated estradiol signaling in immortalized hypothalamic N-38 neurons
TLDR
Results indicate that membrane ERα levels in N-38 neurons are dynamically autoregulated by estradiol, indicating that membrane signaling increased receptor insertion into the cell membrane. Expand
Estradiol stimulates progesterone synthesis in hypothalamic astrocyte cultures.
TLDR
The present results are consistent with the hypothesis that estrogen-positive feedback regulating the LH surge involves stimulating local progesterone synthesis by hypothalamic astrocytes, and indicate that estradiol acts through a membrane-associated receptor to release intracellular stores of Ca(2+). Expand
Membrane-Initiated Estradiol Signaling Regulating Sexual Receptivity
TLDR
Evidence for and against their participation in sexual receptivity by acting in the lordosis-regulating circuit are presented, suggesting a common mechanism through which mERs are coupled to intracellular signaling cascades, not just in regulating reproduction, but in actions throughout the neuraxis including the cortex, hippocampus, striatum, and dorsal root ganglias. Expand
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