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Large-scale eradication of rabies using recombinant vaccinia-rabies vaccine
TLDR
A large-scale campaign of fox vaccination in a 2,200 km2 region of southern Belgium, an area in which rabies is prevalent, reports no case of rabies, either in foxes or in domestic livestock, has been reported.
Oral vaccination of the fox against rabies using a live recombinant vaccinia virus
TLDR
It is found that the administration of vaccinia virus or a recombinant harbouring the rabies surface antigen gene (VVTGgRAB) is innocuous to foxes, and the recombinant virus can elicit the production of titres of rabies-neutralizing antibodies equal or superior to those obtained with conventional vaccine.
Newcastle disease virus fusion protein expressed in a fowlpox virus recombinant confers protection in chickens
TLDR
A cDNA copy of the RNA encoding the fusion (F) protein of Newcastle disease virus (NDV) strain Texas, a velogenic strain of NDV, was obtained and the sequence was determined and an immunological response was induced.
Field use of a vaccinia-rabies recombinant vaccine for the control of sylvatic rabies in Europe and North America.
TLDR
Preliminary data from field trails indicate a significant reduction in the incidence of rabies in vaccinated areas, and despite very good examples of cross-border cooperation, reinfections have occurred in some regions, due to the difficulty of co-ordinating vaccination plans among neighbouring countries.
Coexpression by vaccinia virus recombinants of equine herpesvirus 1 glycoproteins gp13 and gp14 results in potentiated immunity
TLDR
The equine herpesvirus 1 glycoprotein 14 (EHV-1 gp14) gene was cloned, sequenced, and expressed by vaccinia virus recombinants and greatly enhanced the protective efficacy in the hamster challenge model over that obtained with single recombinant.
Protection of mice and swine from pseudorabies virus conferred by vaccinia virus-based recombinants
TLDR
The coexpression of gII and gIII by a single vaccinia virus recombinant resulted in a significantly reduced vaccination dose required to protect mice against PRV challenge and inoculation of piglets with the various vacciniairus-PRV glycoprotein recombinants resulted in protection against virulentPRV challenge as measured by weight gain.
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