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The Yale-Brown Obsessive Compulsive Scale. II. Validity.
The development design and reliability of the Yale-Brown Obsessive Compulsive Scale have been described elsewhere. We focused on the validity of the Yale-Brown Scale and its sensitivity to change.Expand
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The Arizona Sexual Experience Scale (ASEX): reliability and validity.
Although sexual dysfunction is common in psychiatric patients, quantification of sexual dysfunction is limited by the paucity of validated, user-friendly scales. In order to address this problem, theExpand
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Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan.
Brain serotonin content is dependent on plasma levels of the essential amino acid tryptophan. We investigated the behavioral effects of rapid tryptophan depletion in patients inExpand
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Safety, tolerability, and efficacy of psilocybin in 9 patients with obsessive-compulsive disorder.
BACKGROUND Anecdotal reports suggest that psychedelic agents may relieve symptoms of obsessive-compulsive disorder (OCD). This modified double-blind study investigated the safety, tolerability, andExpand
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Depression: the case for a monoamine deficiency.
  • P. Delgado
  • Medicine, Psychology
  • The Journal of clinical psychiatry
  • 30 June 2000
The monoamine hypothesis of depression predicts that the underlying pathophysiologic basis of depression is a depletion in the levels of serotonin, norepinephrine, and/or dopamine in the centralExpand
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Efficacy of fluvoxamine in obsessive-compulsive disorder. A double-blind comparison with placebo.
A six- to eight-week double-blind placebo-controlled trial of the potent and selective serotonin reuptake inhibitor fluvoxamine was conducted in 42 patients with primary obsessive-compulsive disorderExpand
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Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: implications for the role of serotonin in the mechanism of antidepressant action
BACKGROUND Brain serotonin (5-HT) content is dependent on plasma levels of the essential amino acid, tryptophan (TRP). We have previously reported that rapid TRP depletion more frequently reversedExpand
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Serotonin and the neurobiology of depression. Effects of tryptophan depletion in drug-free depressed patients.
OBJECTIVE To investigate the effects of tryptophan depletion in untreated depressed patients. Rapid dietary depletion of the precursor of serotonin synthesis, tryptophan, causes a transient return ofExpand
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Predictors of response to acute treatment of chronic and double depression with sertraline or imipramine.
BACKGROUND The literature on predictors of response to treatment of nonchronic major depression has identified shorter duration of illness, acute onset, and less severity of illness as positiveExpand
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Monoamines and the mechanism of antidepressant action: effects of catecholamine depletion on mood of patients treated with antidepressants.
Brain catecholamines can be rapidly reduced by inhibiting their synthesis with alpha-methyl-para-tyrosine (AMPT). In order to assess the role of catecholamines in antidepressant action AMPTExpand
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