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International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors
The hormone melatonin (5-methoxy-N-acetyltryptamine) is synthesized primarily in the pineal gland and retina, and in several peripheral tissues and organs. In the circulation, the concentration ofExpand
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The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization
One‐third of the ∼400 nonodorant G protein‐coupled receptors (GPCRs) are still orphans. Although a considerable number of these receptors are likely to transduce cellular signals in response toExpand
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New selective ligands of human cloned melatonin MT1 and MT2 receptors
Melatonin has a key role in the circadian rhythm relay to periphery organs. Melatonin exerts its multiple roles mainly through two seven transmembrane domain, G-coupled receptors, namely MT1 or MT2Expand
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Molecular tools to study melatonin pathways and actions.
Melatonin, an indoleamine neurohormone that is synthesized mainly in the pineal gland and derived from 5-HT, has many effects on a wide range of physio-pathological functions. Some of these effectsExpand
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Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?
Melatonin is a neurohormone that has been claimed to be involved in a wide range of physiological functions. Nevertheless, for most of its effects, the mechanism of action is not really known. InExpand
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Functional expression of MT2 (Mel1b) melatonin receptors in human PAZ6 adipocytes.
We investigated whether melatonin could act directly at MT2 receptors on human brown adipocytes to regulate adipocyte physiology. Expand
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Update on melatonin receptors: IUPHAR Review 20
Melatonin receptors are seven transmembrane‐spanning proteins belonging to the GPCR superfamily. In mammals, two melatonin receptor subtypes exist ‐ MT1 and MT2 ‐ encoded by the MTNR1A and MTNR1BExpand
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NRH:quinone reductase 2: an enzyme of surprises and mysteries.
Quinone reductase 2 has been discovered in 1961 and rediscovered in 1997. Because of its sequence homology with quinone reductase 1, it has been suspected to detoxify quinones. Ten years later,Expand
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Identification of the Melatonin-binding SiteMT 3 as the Quinone Reductase 2*
The regulation of the circadian rhythm is relayed from the central nervous system to the periphery by melatonin, a hormone synthesized at night in the pineal gland. Besides two melatonin G-coupledExpand
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IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels
The IUPHAR database integrates peer-reviewed pharmacological, chemical, genetic, functional and anatomical information on the 354 nonsensory G protein-coupled receptors (GPCRs), 71 ligand- gated ion channel subunits and 141 voltage-gated-like ion channels encoded by the human, rat and mouse genomes. Expand
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