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International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors
The hormone melatonin (5-methoxy-N-acetyltryptamine) is synthesized primarily in the pineal gland and retina, and in several peripheral tissues and organs. In the circulation, the concentration ofExpand
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The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization
One‐third of the ∼400 nonodorant G protein‐coupled receptors (GPCRs) are still orphans. Although a considerable number of these receptors are likely to transduce cellular signals in response toExpand
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New selective ligands of human cloned melatonin MT1 and MT2 receptors
Melatonin has a key role in the circadian rhythm relay to periphery organs. Melatonin exerts its multiple roles mainly through two seven transmembrane domain, G-coupled receptors, namely MT1 or MT2Expand
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Molecular tools to study melatonin pathways and actions.
Melatonin, an indoleamine neurohormone that is synthesized mainly in the pineal gland and derived from 5-HT, has many effects on a wide range of physio-pathological functions. Some of these effectsExpand
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Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?
Melatonin is a neurohormone that has been claimed to be involved in a wide range of physiological functions. Nevertheless, for most of its effects, the mechanism of action is not really known. InExpand
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Functional expression of MT2 (Mel1b) melatonin receptors in human PAZ6 adipocytes.
TLDR
We investigated whether melatonin could act directly at MT2 receptors on human brown adipocytes to regulate adipocyte physiology. Expand
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Update on melatonin receptors: IUPHAR Review 20
Melatonin receptors are seven transmembrane‐spanning proteins belonging to the GPCR superfamily. In mammals, two melatonin receptor subtypes exist ‐ MT1 and MT2 ‐ encoded by the MTNR1A and MTNR1BExpand
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NRH:quinone reductase 2: an enzyme of surprises and mysteries.
Quinone reductase 2 has been discovered in 1961 and rediscovered in 1997. Because of its sequence homology with quinone reductase 1, it has been suspected to detoxify quinones. Ten years later,Expand
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Identification of the Melatonin-binding SiteMT 3 as the Quinone Reductase 2*
The regulation of the circadian rhythm is relayed from the central nervous system to the periphery by melatonin, a hormone synthesized at night in the pineal gland. Besides two melatonin G-coupledExpand
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IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels
TLDR
The IUPHAR database integrates peer-reviewed pharmacological, chemical, genetic, functional and anatomical information on the 354 nonsensory G protein-coupled receptors (GPCRs), 71 ligand- gated ion channel subunits and 141 voltage-gated-like ion channels encoded by the human, rat and mouse genomes. Expand
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