HETEROZYGOSITY‐FITNESS CORRELATIONS: A TIME FOR REAPPRAISAL
It is shown that available data are quantitatively and qualitatively consistent with inbreeding‐based theory, and how HFCs can be used to quantify inbreeding load and unravel the structure of natural populations is presented.
Understanding the relationship between the inbreeding coefficient and multilocus heterozygosity: theoretical expectations and empirical data
Microsatellite genotypes at 138 loci spanning all 26 autosomes of the sheep genome were used to investigate the relationship between inbreeding coefficient and multilocus heterozygosity and detected evidence of inbreeding depression for morphological traits.
Reliable selfing rate estimates from imperfect population genetic data
It is shown here that, in the absence of gametic disequilibrium, the multilocus structure can be used to derive estimates of s independent of FIS and free of technical biases, which opens the way to make use of the ever‐growing number of published population genetic studies, in addition to the more demanding progeny‐array approaches, to investigate selfing rates.
Heterozygosity–fitness correlations: new perspectives on old problems
- P. David
- 1 May 1998
This issue might soon be resolved provided clear hypotheses and definitions are used and the problem of the neutrality of allozyme variation is not identified with the related issue of HFC, as well as new empirical & theoretical tools.
The coupling hypothesis: why genome scans may fail to map local adaptation genes
It is argued that endogenous genetic barriers are often more likely than local adaptation to explain the majority of Fst‐outlying loci observed in genome scan approaches – even when these are correlated to environmental variables.
Mapping phenotypes: canalization, plasticity and developmental stability
A general eco-evolutionary framework for understanding bioinvasions.
A review of relationships between interspecific competition and invasions in fruit flies (Diptera: Tephritidae)
The potential importance of interspecific competition and competitive displacement among different tephritid species is evaluated in the context of recent invasions.
Introgression patterns in the mosaic hybrid zone between Mytilus edulis and M. galloprovincialis
The genetic structure of the mosaic hybrid zone between the marine mussels Mytilus edulis and M. galloprovincialis is analysed using three length‐polymorphic PCR loci as neutral and diagnostic markers along the Atlantic coast of Europe, indicating a strong genetic barrier within all transition zones.
High-throughput sequencing reveals inbreeding depression in a natural population
- J. Hoffman, F. Simpson, K. Dasmahapatra
- BiologyProceedings of the National Academy of Sciences
- 28 February 2014
High-throughput DNA sequencing was used to estimate genome-wide heterozygosity based on over 10,000 loci and found it to accurately reflect inbreeding, providing the strongest evidence to date of an HFC being due to inbreeding depression in a natural population lacking a pedigree.