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Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology.
BACKGROUND The study was designed to verify the concept of plaques "at risk" and whether inflammation could play a role in plaque rupture and thrombosis. METHODS AND RESULTS In 20 patients who hadExpand
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Immunopolarization of CD4+ and CD8+ T Cells to Type-1–Like is Associated with Melanocyte Loss in Human Vitiligo
Vitiligo is an autoimmune condition characterized by loss of epidermal melanocytes. High frequencies of melanocyte-reactive cytotoxic T cells in the peripheral blood of vitiligo patients and theExpand
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UVB radiation preferentially induces recruitment of memory CD4+ T cells in normal human skin: long-term effect after a single exposure.
Acute, low-doses of ultraviolet (UV)-B radiation affect the immune competent cells of the skin immune system. In this study, we examined the time-dependent changes of the cutaneous T cell populationExpand
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The skin immune system (SIS): distribution and immunophenotype of lymphocyte subpopulations in normal human skin.
The complexity of immune response-associated cells present in normal human skin was recently redefined as the skin immune system (SIS). In the present study, the exact immunophenotypes of lymphocyteExpand
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IgG4 antibodies in Egyptian patients with schistosomiasis.
Serum immunoglobulins were determined in 40 Egyptian patients with schistosomiasis. In addition to the well-established elevation in total IgE, a striking imbalance in the IgG subclass levels wasExpand
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Altered Expression of Interferon‐&ggr; and Interleukin‐4 in Inflammatory Bowel Disease
Summary: Experimental data indicate that mucosal CD4+ T cells play an important role in the pathogenesis of inflammatory bowel disease (IBD). Based on the pattern of cytokine production, CD4+ T cellsExpand
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Efficient debridement of necrotic wounds using proteolytic enzymes derived from Antarctic krill: a double‐blind, placebo‐controlled study in a standardized animal wound model
Wound healing can be accelerated by removing necrotic tissue. Various methods of wound debridement have been developed, including enzymatic debridement. Recently potent proteolytic enzymes wereExpand
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Protection from experimental colitis by theaflavin‐3,3′‐digallate correlates with inhibition of IKK and NF‐κB activation
Inflammatory bowel disease (IBD) is associated with activation of nuclear factor κ B (NF‐κB) involved in regulating the expression of inducible nitric oxide synthase (iNOS) and proinflammatoryExpand
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In contrast to their murine counterparts, normal human keratinocytes and human epidermoid cell lines A431 and HaCaT fail to express IL‐10 mRNA and protein
In mice, keratinocyte‐derived IL‐10 is up‐regulated by ultraviolet‐B (UVB) radiation and plays a major role in UVB‐induced immunosuppression. The present study was designed to examine whether aExpand
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Melanocyte-specific immune response in melanoma and vitiligo: two faces of the same coin?
The appearance of depigmentation during the course of malignant melanoma has been considered a good prognostic sign. Is it only a side-effect, informative of the immune system's response to theExpand
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