P. Darlu

Publications99
h-index21
Citations2,248
Highly Influential Citations118
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When does the incongruence length difference test fail?
TLDR
The ILD test has only limited power to detect incongruence caused by differences in the evolutionary conditions or in the tree topology, except when numerous characters are present and the substitution rate is homogeneous from site to site.
Escherichia coli molecular phylogeny using the incongruence length difference test.
TLDR
Interestingly, the most primitive taxon within E. coli in terms of branching pattern, i.e., the B2 group, includes highly virulent extraintestinal strains with derived characters (extraintestinal virulence determinants) occurring on its own branch.
Worldwide distribution of NAT2 diversity: Implications for NAT2 evolutionary history
TLDR
Patterns of sequence variation at NAT2 are consistent with selective neutrality in all sub-Saharan African populations investigated, whereas the high level of population differentiation between Europeans and East Asians inferred from SNPs could suggest population-specific selective pressures acting at this locus.
Very virulent infectious bursal disease virus: reduced pathogenicity in a rare natural segment-B-reassorted isolate.
TLDR
One of the possible naturally occurring reassortant strains, which exhibited a segment A related to the vvIBDV cluster whereas its segment B was not, was thoroughly sequenced (coding sequence of both segments) and submitted to a standardized experimental characterization of its acute pathogenicity.
A cladistic analysis of the Trichostrongyloidea (Nematoda).
Evolutionary Implications of the Frequent Horizontal Transfer of Mismatch Repair Genes
Revisiting Neandertal diversity with a 100,000 year old mtDNA sequence
Arylamine N-Acetyltransferase 2 (NAT2) Genetic Diversity and Traditional Subsistence: A Worldwide Population Survey
Arylamine N-acetyltransferase 2 (NAT2) is involved in human physiological responses to a variety of xenobiotic compounds, including common therapeutic drugs and exogenous chemicals present in the…
Role of Intraspecies Recombination in the Spread of Pathogenicity Islands within the Escherichia coli Species
TLDR
The results of this study demonstrate for the first time that conjugative transfer and homologous DNA recombination play a major role in horizontal transfer of a pathogenicity island within the species E. coli.
Exploring a phylogenetic approach for the detection of correlated substitutions in proteins.
TLDR
The phylogenetic reconstruction of 15 sets of homologous proteins to assess, under different conditions, whether a significant amount of coevolving sites can be detected shows an important sensitivity of the detection of cosubstituting sites to the model used for the phylogenetic reconstructions.
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